Is there an association between oral submucous fibrosis and ABO blood grouping?

被引:3
作者
Reddy, Venu K. Gopal [1 ]
Moon, Ninad J. [2 ]
Sharva, Vijayta [3 ]
Guruprasad [4 ]
Reddy, Eshwar K. [5 ]
Chandralkala, Sujitha [6 ]
机构
[1] Peoples Coll Dent Sci & Res Ctr, Dept Publ Hlth Dent, Bhopal 462037, Madhya Pradesh, India
[2] RKDF Dent Coll, Dept Periodont, Bhopal, India
[3] Peoples Dent Acad, Dept Publ Hlth Dent, Bhopal, India
[4] Governament Dent Coll, Dept Oral Med & Radiol, Shimla, Himachal Prades, India
[5] Southern Inst Med Sci Coll Physiotherapy, Dept Physiotherapy, Guntur, Andhra Pradesh, India
[6] Peoples Coll Res & Technol, Dept English, Bhopal, Madhya Pradesh, India
关键词
ABO blood group; areca nut; odds ratio; oral submucous fibrosis; premalignant condition; CANCER; RISK; GENE;
D O I
10.4103/0973-1482.151857
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background: Oral submucous fibrosis (OSMF) is one of the most common premalignant conditions in Indian subcontinent due to the traditional use of Areca nut and its various preparations. The genetic predisposition has also been reported in its etiopathogenesis. The rate of malignant transformation is between 7% to 14%. Aim: To evaluate whether ABO blood group is related to OSMF risk. Subjects and Methods: It was a cross-sectional hospital-based study. A convenient sample of 164 study subjects constituted the cases and 180 subjects constituted the comparison group. Statistical Analysis Used: The results were analyzed using chi-square test and odds ratio. Results: The chi-square analysis could not establish any significant relationship between OSMF and ABO blood group. But, when the strength of the association was measured using odds ratio, subjects with blood group A had 1.181 times higher risk of developing OSMF in comparison to other groups. Conclusion: The subjects with blood group A were at higher risk of developing OSMF in comparison to others. By performing blood group determination using a routine method at outreach programs, the susceptible individuals can be identified and counselled to quit the habit, thereby avoiding potential complications.
引用
收藏
页码:126 / 130
页数:5
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