Synthesis of a 1,2,7,8-tetraoxa-spiro[5.5]undecane

被引：19

作者：

Zhang, Qi ^{[1
]}

Li, Yun ^{[1
]}

Wu, Yi-Kang ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Bio Organic & Nat Prod Chem, Shanghai 200032, Peoples R China

来源：

CHINESE JOURNAL OF CHEMISTRY | 2007年 / 25卷 / 09期

关键词：

peroxide; antimalarial; artemisinin; hydrogen peroxide; spiro compound;

D O I：

10.1002/cjoc.200790242

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Synthesis of a new spiro organic peroxide is described. The peroxy bonds were incorporated into the substrate framework via an acid-catalyzed ketal exchange reaction using hydrogen peroxide as the source of peroxy linkage. The hydroperoxyl groups were then bonded at the OH ends via Hg(II)-induced electrophilic additions to the C-C double bonds, giving a novel sprio structure with one peroxy bond in each of the two six-membered rings. The ester functionalities in the side chains also make it possible to conduct further structural modifications.

引用

页码：1304 / 1308

页数：5

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