Postoperative analgesic efficacy of perioperative intravenous lidocaine infusion in patients undergoing septorhinoplasty: a prospective, randomized, double-blind study

被引:11
作者
Ates, Irem [1 ]
Aydin, Muhammed Enes [1 ]
Ahiskalioglu, Ali [1 ,3 ]
Ahiskalioglu, Elif Oral [1 ]
Kaya, Zulkuf [2 ]
Gozeler, Mustafa Sitki [2 ]
机构
[1] Ataturk Univ, Dept Anesthesiol & Reanimat, Sch Med, TR-25070 Erzurum, Turkey
[2] Ataturk Univ, Dept Otorhinolaryngol, Sch Med, Erzurum, Turkey
[3] Ataturk Univ, Sch Med, Clin Res Dev & Design Applicat & Res Ctr, TR-25240 Erzurum, Turkey
关键词
Intravenous lidocaine infusion; Septorhinoplasty; Postoperative analgesia; Pain; SYSTEMIC LIDOCAINE; PAIN; RECOVERY; DURATION; SURGERY;
D O I
10.1007/s00405-020-05801-6
中图分类号
R76 [耳鼻咽喉科学];
学科分类号
100213 ;
摘要
Purpose Intravenous lidocaine infusion has been used for postoperative analgesia in many surgical procedures in recent years. The aim of this randomized, double-blind study was to investigate the postoperative analgesic efficacy of perioperative intravenous lidocaine infusion in patients undergoing septorhinoplasty surgery. Materials and methods Forty-eight American Society of Anesthesiologists I and II patients, aged 18-40 years scheduled for septorhinoplasty surgery, were assigned into two groups. Before anesthesia induction, patients in the lidocaine group (Group L, n = 24) received an intravenous bolus infusion of 1.5 mg/kg lidocaine followed by a continuous infusion of 1.5 mg/kg/h during the operation and until the end of the first postoperative hour. Patients in the control group (Group C, n = 24) received normal saline according to the same protocol. In the postoperative period, 50 mg dexketoprofen trometamol was administered and repeated every 12 h. Postoperative pain scores, rescue analgesia, intraoperative opioid requirements, and side effects were recorded. Results Postoperative pain scores were significantly lower in Group L than in Group C at postoperative 30 min, 1, 2, 4, 8, 12 and 24 h (p < 0.05). There was no difference between groups intraoperative remifentanil consumption (p > 0.05). Rescue analgesia use was statistically significantly higher in Group C than in Group L (12/24 versus 1/24, respectively, p = 0.001). Postoperative nausea was statistically higher in Group C than in Group L (13/24 versus 5/24 respectively, p = 0.017), whereas other side-effects were similar for the two groups (p > 0.05). Discussion We recommended the use of intravenous lidocaine infusion for intraoperatively and first postoperative hours in septorhinoplasty surgery as it reduces pain scores and the need for additional opioid use.
引用
收藏
页码:1095 / 1100
页数:6
相关论文
共 26 条
[1]   History of the development and evolution of local anesthesia since the coca leaf [J].
Calatayud, J ;
González, A .
ANESTHESIOLOGY, 2003, 98 (06) :1503-1508
[2]   Serum Concentrations of Lidocaine During Bariatric Surgery [J].
Carabalona, Jean-Francois ;
Delwarde, Benjamin ;
Duclos, Antoine ;
Le Goff, Mary-Charlotte ;
Moulsma, Mustapha ;
Citterio-Quentin, Antony ;
Bouffard, Yves ;
Rimmele, Thomas .
ANESTHESIA AND ANALGESIA, 2020, 130 (01) :E5-E8
[3]   The comparison of single-dose preemptive intravenous ibuprofen and paracetamol on postoperative pain scores and opioid consumption after open septorhinoplasty: a randomized controlled study [J].
Celik, Erkan Cem ;
Kara, Duygu ;
Koc, Ersen ;
Yayik, Ahmet Murat .
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY, 2018, 275 (09) :2259-2263
[4]   Clinical Efficacy of Intravenous Lidocaine for Thyroidectomy: A Prospective, Randomized, Double-Blind, Placebo-Controlled Trial [J].
Choi, Geun Joo ;
Kang, Hyun ;
Ahn, Eun Jin ;
Oh, Jong In ;
Baek, Chong Wha ;
Jung, Yong Hun ;
Kim, Jin Yun .
WORLD JOURNAL OF SURGERY, 2016, 40 (12) :2941-2947
[5]   Systemic administration of lidocaine reduces morphine requirements and postoperative pain of patients undergoing thoracic surgery after propofol-remifentanil-based anaesthesia [J].
Cui, Weihua ;
Li, Yanping ;
Li, Shuren ;
Wang, Rulong ;
Li, Junfa .
EUROPEAN JOURNAL OF ANAESTHESIOLOGY, 2010, 27 (01) :41-46
[6]   Systemic lidocaine fails to improve postoperative morphine consumption, postoperative recovery and quality of life in patients undergoing posterior spinal arthrodesis. A double-blind, randomized, placebo-controlled trial [J].
Dewinter, G. ;
Moens, P. ;
Fieuws, S. ;
Vanaudenaerde, B. ;
Van de Velde, M. ;
Rex, S. .
BRITISH JOURNAL OF ANAESTHESIA, 2017, 118 (04) :576-585
[7]  
Estebe JP, 2017, BEST PRACT RES-CLIN, V31, P513, DOI 10.1016/j.bpa.2017.05.005
[8]   LIDOCAINE INFUSIONS - EFFECT OF DURATION AND METHOD OF DISCONTINUATION ON RECURRENCE OF ARRHYTHMIAS AND PHARMACOKINETIC VARIABLES [J].
FREDRICK, DS ;
BOERSMA, RB .
AMERICAN JOURNAL OF HOSPITAL PHARMACY, 1979, 36 (06) :778-781
[9]   Poorly controlled postoperative pain: prevalence, consequences, and prevention [J].
Gan, Tong J. .
JOURNAL OF PAIN RESEARCH, 2017, 10 :2287-2298
[10]   Does a single-dose preemptive intravenous ibuprofen have an effect on postoperative pain relief after septorhinoplasty? [J].
Gozeler, Mustafa Sitki ;
Sakat, Muhammed Sedat ;
Kilic, Korhan ;
Ozmen, Ozgur ;
Can, Abdullah ;
Ince, Ilker .
AMERICAN JOURNAL OF OTOLARYNGOLOGY, 2018, 39 (06) :726-730