Plasticity and Dedifferentiation within the Pancreas: Development, Homeostasis, and Disease

被引：120

作者：

Puri, Sapna ^{[1
]}

Folias, Alexandra E. ^{[1
]}

Hebrok, Matthias ^{[1
]}

机构：

[1] Univ Calif San Francisco, Dept Med, Ctr Diabet, San Francisco, CA 94143 USA

来源：

CELL STEM CELL | 2015年 / 16卷 / 01期

关键词：

BETA-CELL DEDIFFERENTIATION; ONCOGENIC KRAS; ACINAR-CELL; ALPHA-CELL; TRANSCRIPTION FACTORS; ENDOCRINE PANCREAS; PROGENITOR CELLS; DUCTAL CELLS; DIFFERENTIATION; EXPRESSION;

D O I：

10.1016/j.stem.2014.11.001

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Cellular identity is established by genetic, epigenetic, and environmental factors that regulate organogenesis and tissue homeostasis. Although some flexibility in fate potential is beneficial to overall organ health, dramatic changes in cellular identity can have disastrous consequences. Emerging data within the field of pancreas biology are revising current beliefs about how cellular identity is shaped by developmental and environmental cues under homeostasis and stress conditions. Here, we discuss the changes occurring in cellular states upon fate modulation and address how our understanding of the nature of this fluidity is shaping therapeutic approaches to pancreatic disorders such as diabetes and cancer.

引用

页码：18 / 31

页数：14

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