Investigating the self-assembly and shape transformation of poly(ethylene glycol)-b-poly(d,l-lactide) (PEG-PDLLA) polymersomes by tailoring solvent-polymer interactions

被引：18
作者：
Pijpers, Imke A. B. [1 ]
Meng, Fenghua [2 ]
van Hest, Jan C. M. [1 ]
Abdelmohsen, Loai K. E. A. [1 ]
机构：
[1] Eindhoven Univ Technol, ICMS, Dept Bioorgan Chem, Het Kranenveld 14, NL-5600 MB Eindhoven, Netherlands
[2] Soochow Univ, Coll Chem Chem Engn & Mat Sci, Biomed Polymers Lab, Suzhou 215123, Peoples R China
来源：
POLYMER CHEMISTRY | 2020年 / 11卷 / 02期
基金：
中国国家自然科学基金;
关键词：
BLOCK; NANOPARTICLES; MORPHOLOGIES; VESICLES;
D O I：
10.1039/c9py01089k
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
The assembly of amphiphilic block copolymers in well-defined polymer nanoparticles is an intricate interplay between polymer composition, method of assembly and the properties of the organic solvent used to dissolve the polymer building blocks. Remarkably, the role of organic solvent composition has been much less studied in comparison to the other two parameters. Here we have systematically investigated the effect of organic solvent composition, namely, the ratio between tetrahydrofuran and dioxane, on the self-assembly of PEG-PDLLA copolymers into polymer vesicles and their subsequent shape change in different topologies. Uncovering such physical basis unlocks new opportunities for the development of complex nanoparticles without the need of extended polymer engineering processes.
引用
收藏
页码：275 / 280
页数：6
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