Backbone dynamics and amide proton exchange at the two sides of the eremomycin dimer by 15N NMR

被引：10
|
作者：
Batta, G
Sztaricskai, F
Makarova, MO
Gladkikh, EG
Pogozheva, VV
Berdnikova, TF
机构：
[1] Hungarian Acad Sci, Antibiot Res Grp, H-4010 Debrecen, Hungary
[2] Russian Acad Med Sci, Gause Inst New Antibiot, Moscow 119867, Russia
来源：
CHEMICAL COMMUNICATIONS | 2001年 / 05期
关键词：
D O I：
10.1039/b010144n
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
N-15-labelling of the glycopeptide antibiotic eremomycin has made possible the dynamic characterization of the two sides of the dimer; in the presence of acetate anion the backbone amides are dynamically equivalent and the fastest amide proton exchange rate was found at the heart of the binding pocket.
引用
收藏
页码：501 / 502
页数：2
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