1,25-dihydroxyvitamin D3 (1,25-(OH)2D3) Induces Cell Apoptosis of Human Mesangial Cells

被引：0

作者：

Zhang, Chunjiang ^{[1
]}

Liu, Gang ^{[1
]}

Zhao, Dan ^{[1
]}

Lin, Zhifeng ^{[1
]}

Yang, Rui ^{[1
]}

Gu, Jie ^{[2
]}

Nie, Qingqing ^{[2
]}

Yang, Xiaoping ^{[1
,3
]}

机构：

[1] Shihezi Univ, Affiliated Hosp 1, Sch Med, Dept Nephrol, Shihezi 832000, Xinjiang, Peoples R China

[2] Shihezi Univ, Med Coll, Shihezi 832000, Xinjiang, Peoples R China

[3] Shihezi Univ, Affiliated Hosp 1, Sch Med, Dept Nephrol, 107 North 2nd Rd, Shihezi, Xinjiang, Peoples R China

来源：

INTERNATIONAL JOURNAL OF HUMAN GENETICS | 2022年 / 22卷 / 03期

关键词：

Apoptosis; Human Mesangial Cell; 1; Mechanism; Mesangial Proliferative Glomerulonephritis; VITAMIN-D; RAPID RESPONSE; RECEPTOR; MITOCHONDRIAL; INVOLVEMENT; INHIBITION; ACTIVATION; PATHWAYS; BINDING;

D O I：

10.31901/24566330.2022/22.03.821

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

In China, primary glomerulonephritis is the leading cause of end-stage renal disease (ESRD), and patients who require kidney transplantation often with ESRD. Glomerulonephritis primary's most prevalent subtype is Mesangial proliferative glomerulonephritis (MsPGN). Although the cell apoptosis of human mesangial cells (HMCs) may be harmful in MsPGN, it plays a major role in the elimination of excessive HMCs and reparative glomerular remodelling after inflammation. A powerful mitogen for growing mesangial cells is epidermal growth factor (EGF). Therefore, it is possible to induce the proliferation of HMCs by incubating with EGF in vitro. 1,25(OH)2D3(VD3) may cause cell death in HMCs via activating AKT, caspase-3, caspase-9, JNK, and ERK, as well as elevating Bax and Bad levels.

引用

页码：215 / 224

页数：10

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