High-throughput drug discovery: what can we exulect from HTS?

被引：124

作者：

Gribbon, P ^{[1
]}

Sewing, A ^{[1
]}

机构：

[1] Pfizer Global Res & Dev, Lab Discovery Technol, Sandwich CT13 9NJ, Kent, England

来源：

DRUG DISCOVERY TODAY | 2005年 / 10卷 / 01期

关键词：

D O I：

10.1016/S1359-6446(04)03275-1

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

引用

页码：17 / 22

页数：6

共 47 条

[1]

Alanine A, 2003, COMB CHEM HIGH T SCR, V6, P51

[2] Integration of virtual and high-throughput screening [J].

Bajorath, F .

NATURE REVIEWS DRUG DISCOVERY, 2002, 1 (11) :882-894

[3] Property-based design of GPCR-targeted library [J].

Balakin, KV ;

Tkachenko, SE ;

Lang, SA ;

Okun, I ;

Ivashchenko, AA ;

Savchuk, NP .

JOURNAL OF CHEMICAL INFORMATION AND COMPUTER SCIENCES, 2002, 42 (06) :1332-1342

[4] Hit and lead generation:: Beyond high-throughput screening [J].

Bleicher, KH ;

Böhm, HJ ;

Müller, K ;

Alanine, AI .

NATURE REVIEWS DRUG DISCOVERY, 2003, 2 (05) :369-378

[5]

Caldwell Gary W., 2001, Current Topics in Medicinal Chemistry, V1, P353, DOI 10.2174/1568026013394949

[6] Physical chemical properties of oral drug candidates in the discovery and exploratory development settings [J].

Curatolo, W .

PHARMACEUTICAL SCIENCE & TECHNOLOGY TODAY, 1998, 1 (09) :387-393

[7]

Darvas Ferenc, 2002, Current Topics in Medicinal Chemistry, V2, P1287, DOI 10.2174/1568026023392841

[8] Profiling drug-like properties in discovery research [J].

Di, L ;

Kerns, EH .

CURRENT OPINION IN CHEMICAL BIOLOGY, 2003, 7 (03) :402-408

[9] The application of non-combinatorial chemistry to lead discovery [J].

Everett, J ;

Gardner, M ;

Pullen, F ;

Smith, GF ;

Snarey, M ;

Terrett, N .

DRUG DISCOVERY TODAY, 2001, 6 (15) :779-785

[10] 1536-well assay plates: when do they make sense? [J].

Garyantes, TK .

DRUG DISCOVERY TODAY, 2002, 7 (09) :489-490

← 1 2 3 4 5 →