Sterol homeostasis in the budding yeast, Saccharomyces cerevisiae

被引：36
作者：
Henneberry, AL
Sturley, SL
机构：
[1] Columbia Univ, Med Ctr, Inst Human Nutr, New York, NY 10032 USA
[2] Columbia Univ, Med Ctr, Dept Pediat, New York, NY 10032 USA
来源：
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2005年 / 16卷 / 02期
关键词：
yeast; ergosterol; cholesterol; transport; neurodegeneration;
D O I：
10.1016/j.semcdb.2005.01.006
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Lipid related diseases, such as obesity, type 2 diabetes, and atherosclerosis are epidemics in developed civilizations. A common underlying factor among these syndromes is excessive subcellular accumulation of lipids such as cholesterol and triglyceride. The homeostatic events that govern these metabolites are understood to varying degrees of sophistication. We describe here the utilization of a genetically powerful model organism, budding yeast, to identify and characterize novel aspects of sterol and lipid homeostasis. (c) 2005 Published by Elsevier Ltd.
引用
收藏
页码：155 / 161
页数：7
相关论文
共 59 条
[1]   Identification and characterization of major lipid particle proteins of the yeast Saccharomyces cerevisiae [J].
Athenstaedt, K ;
Zweytick, D ;
Jandrositz, A ;
Kohlwein, SD ;
Daum, G .
JOURNAL OF BACTERIOLOGY, 1999, 181 (20) :6441-6448
[2]   SACCHAROMYCES-CEREVISIAE CONTAINS 2 FUNCTIONAL GENES ENCODING 3-HYDROXY-3-METHYLGLUTARYL-COENZYME-A REDUCTASE [J].
BASSON, ME ;
THORSNESS, M ;
RINE, J .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (15) :5563-5567
[3]   A role for yeast oxysterol-binding protein homologs in endocytosis and in the maintenance of intracellular sterol-lipid distribution [J].
Beh, CT ;
Rine, J .
JOURNAL OF CELL SCIENCE, 2004, 117 (14) :2983-2996
[4]  
Beh CT, 2001, GENETICS, V157, P1117
[5]   A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood [J].
Brown, MS ;
Goldstein, JL .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (20) :11041-11048
[6]   Cholesterol in Alzheimer's disease and tauopathy [J].
Burns, M ;
Duff, K .
ALZHEIMER'S DISEASE: VASCULAR ETIOLOGY AND PATHOLOGY, 2002, 977 :367-375
[7]   Niemann-Pick C1 disease gene: Homology to mediators of cholesterol homeostasis [J].
Carstea, ED ;
Morris, JA ;
Coleman, KG ;
Loftus, SK ;
Zhang, D ;
Cummings, C ;
Gu, J ;
Rosenfeld, MA ;
Pavan, WJ ;
Krizman, DB ;
Nagle, J ;
Polymeropoulos, MH ;
Sturley, SL ;
Ioannou, YA ;
Higgins, ME ;
Comly, M ;
Cooney, A ;
Brown, A ;
Kaneski, CR ;
BlanchetteMackie, EJ ;
Dwyer, NK ;
Neufeld, EB ;
Chang, TY ;
Liscum, L ;
Strauss, JF ;
Ohno, K ;
Zeigler, M ;
Carmi, R ;
Sokol, J ;
Markie, D ;
ONeill, RR ;
vanDiggelen, OP ;
Elleder, M ;
Patterson, MC ;
Brady, RO ;
Vanier, MT ;
Pentchev, PG ;
Tagle, DA .
SCIENCE, 1997, 277 (5323) :228-231
[8]   Chinese hamster ovary cell mutants affecting cholesterol metabolism [J].
Chang, TY ;
Hasan, MT ;
Chin, J ;
Chang, CCY ;
Spillane, DM ;
Chen, J .
CURRENT OPINION IN LIPIDOLOGY, 1997, 8 (02) :65-71
[9]   CHOLESTEROL INTERACTION WITH RECOMBINANT HUMAN STEROL CARRIER PROTEIN-2 [J].
COLLES, SM ;
WOODFORD, JK ;
MONCECCHI, D ;
MYERSPAYNE, SC ;
MCLEAN, LR ;
BILLHEIMER, JT ;
SCHROEDER, F .
LIPIDS, 1995, 30 (09) :795-803
[10]  
Daum G, 1998, YEAST, V14, P1471, DOI 10.1002/(SICI)1097-0061(199812)14:16<1471::AID-YEA353>3.0.CO
123456