1-Aryl-6,7-methylenedioxy-3H-quinazolin-4-ones as anticonvulsant agents

被引：63
作者：
Zappalà, M
Grasso, S
Micale, N
Zuccalà, G
Menniti, FS
Ferreri, G
De Sarro, G
De Micheli, C
机构：
[1] Univ Messina, Dipartimento Farmacochim, I-98168 Messina, Italy
[2] Pfizer Inc, Global Res & Dev, Groton, CT 06340 USA
[3] Univ Catanzaro, Dipartimento Med Sperimentale & Clin, I-88100 Catanzaro, Italy
[4] Univ Milan, Ist Chim Farmaceut, I-20131 Milan, Italy
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 24期
关键词：
D O I：
10.1016/j.bmcl.2003.09.032
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A set of novel 1-aryl-6,7-methylenedioxy-3H-quinazolin-4-(thi)ones (3a-f) has been designed and screened as anticonvulsant agents in DBA/2 mice. The new compounds are provided with anticonvulsant properties comparable to those of GYKI 52466. To clarify the mode of action, their affinity for the quinazolinone/2,3-benzodiazepine site of the AMPA receptor complex has been assayed. (C) 2003 Elsevier Ltd. All rights reserved.
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收藏
页码：4427 / 4430
页数：4
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