Advances in Pathogenesis of Sjogren's Syndrome

被引：28

作者：

Tian, Yao ^{[1
]}

Yang, Hongyi ^{[1
]}

Liu, Na ^{[1
]}

Li, Yan ^{[2
]}

Chen, Jie ^{[3
]}

机构：

[1] Nanchang Univ, Dept Rheumatol & Clin Immunol, Jiangxi Prov Peoples Hosp, Nanchang, Jiangxi, Peoples R China

[2] Xiamen Univ, Dept Rheumatol & Clin Immunol, Affiliated Hosp 1, Xiamen, Peoples R China

[3] Nanchang Univ, Dept Sci & Techonol, Jiangxi Prov Peoples Hosp, Nanchang, Jiangxi, Peoples R China

来源：

JOURNAL OF IMMUNOLOGY RESEARCH | 2021年 / 2021卷

关键词：

GLAND EPITHELIAL-CELLS; LONG NONCODING RNAS; SALIVARY-GLANDS; DENDRITIC CELLS; DEFICIENT MICE; TH17; CELLS; T-CELLS; EXPRESSION; MOUSE; INTERFERON;

D O I：

10.1155/2021/5928232

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Sjogren's syndrome (SS) is a chronic autoimmune disease of unknown etiology that mainly involves exocrine glands. Patients present with dry mouth and eyes, fever, arthralgia, and other systemic symptoms. In severe cases, the quality of life of patients is affected. At present, there is no cure for SS, and the treatment options are extremely limited. In recent years, studies of patients and animal models have identified abnormalities of immune cell function and cytokines to be involved in SS. A systematic review of the literature may clarify the etiology and pathogenesis of SS, as well as provide a theoretical basis for the development of new drugs for the treatment of SS.

引用

页数：8

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