Diffusion Behavior of Drug Molecules in Acrylic Pressure-Sensitive Adhesive

被引：23

作者：

Chen, Xuexue ^{[2
]}

Wang, Yaxin ^{[2
]}

Cheng, Zhipeng ^{[2
]}

Wei, Jie ^{[3
]}

Shi, Yifeng ^{[1
]}

Qian, Jun ^{[2
]}

机构：

[1] Hangzhou Rongfang Pressure Sensit New Mat Co Ltd, Shanghai 200237, Peoples R China

[2] East China Univ Sci & Technol, Key Lab Adv Polymer Mat Shanghai, Sch Mat Sci & Engn, Shanghai 200237, Peoples R China

[3] East China Univ Sci & Technol, Key Lab Ultrafine Mat Minist Educ, Sch Mat Sci & Engn, Shanghai 200237, Peoples R China

来源：

ACS OMEGA | 2020年 / 5卷 / 16期

基金：

中国国家自然科学基金;

关键词：

SOLVENT DIFFUSION; FREE-VOLUME; POLYMER; DYNAMICS; SIMULATION; WATER; MEMBRANES; SYSTEMS;

D O I：

10.1021/acsomega.0c00491

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Acrylic pressure-sensitive adhesive (PSA) is widely used in transdermal drug delivery systems, while the diffusion behavior of drug molecules in PSA is of great importance. In this paper, PSAs with different cross-link densities were prepared by adjusting the ratio of cross-linkers. The effects of cross-link density and temperature on the diffusion of drugs in PSA were investigated by Fourier transform infrared attenuated total reflectance and molecular dynamics simulation. The consistency between the experimental and simulation results demonstrated that molecular dynamics simulation could be used to predict the diffusion behavior of drugs in PSA. The results showed that free volume and the wriggling of polymer chains are positively related to the diffusion coefficient of drug molecules, while hydrogen bonds hinder drug diffusion.

引用

页码：9408 / 9419

页数：12

共 45 条

[1]

[Anonymous], 2013, IAJPR

[2] Aspect of adhesives in transdermal drug delivery systems [J].

Banerjee, Subham ;

Chattopadhyay, Pronobesh ;

Ghosh, Animesh ;

Datta, Pinaki ;

Veer, Vijay .

INTERNATIONAL JOURNAL OF ADHESION AND ADHESIVES, 2014, 50 :70-84

[3] Diffusion and Aggregation of Sodium Fluorescein in Aqueous Solutions [J].

Casalini, Tommaso ;

Salvalaglio, Matteo ;

Perale, Giuseppe ;

Masi, Maurizio ;

Cavallotti, Carlo .

JOURNAL OF PHYSICAL CHEMISTRY B, 2011, 115 (44) :12896-12904

[4]

Comyn J., 1985, POLYM PERMEABILITY, DOI [DOI 10.1007/978-94-009-4858-7, 10.1007/978-94-009-4858-7_1]

[5] DIFFUSION OF BROWNIAN SPHERES IN SEMIDILUTE POLYMER-SOLUTIONS [J].

CUKIER, RI .

MACROMOLECULES, 1984, 17 (02) :252-255

[6] Acrylic pressure-sensitive adhesive for transdermal drug delivery systems [J].

Czech, Zbigniew ;

Kurzawa, Rafal .

JOURNAL OF APPLIED POLYMER SCIENCE, 2007, 106 (04) :2398-2404

[7]

Frisch H. L., 2006, CRIT REV SOLID STATE, V11, P187

[8] PGSE-NMR STUDIES OF SOLVENT DIFFUSION IN POLY(N-ISOPROPYLACRYLAMIDE) COLLOIDAL MICROGELS [J].

GRIFFITHS, PC ;

STILBS, P ;

CHOWDHRY, BZ ;

SNOWDEN, MJ .

COLLOID AND POLYMER SCIENCE, 1995, 273 (04) :405-411

[9]

Haile J.M., 1993, Molecular Dynamics Simulation: Elementary Methods

[10] Effect of Adhesive Layer Thickness and Drug Loading on Estradiol Crystallization in a Transdermal Drug Delivery System [J].

Imani, Mohammad ;

Lahooti-Fard, Farzad ;

Taghizadeh, Seyyed Mojtaba ;

Takrousta, Mitra .

AAPS PHARMSCITECH, 2010, 11 (03) :1268-1275

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