ClickFerrophos: New chiral ferrocenyl phosphine ligands synthesized by Click Chemistry and the use of their metal complexes as catalysts for asymmetric hydrogenation and allylic substitution

被引：85

作者：

Fukuzawa, Shin-ichi ^{[1
]}

Oki, Hiroshi ^{[1
]}

Hosaka, Mitsuteru ^{[1
]}

Sugasawa, Jun ^{[1
]}

Kikuchi, Satoshi ^{[1
]}

机构：

[1] Chuo Univ, Inst Sci & Engn, Dept Appl Chem, Bunkyo Ku, Tokyo 1128551, Japan

来源：

ORGANIC LETTERS | 2007年 / 9卷 / 26期

关键词：

D O I：

10.1021/ol702519f

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The new ferrocenyl P,P- and P,N-ligands 5 and 6 (collectively, '' ClickFerrophos '') were readily prepared in four steps using Click Chemistry methodology, starting from the commercially available aminoferrocene 1. Rhodium and ruthenium complexes of ClickFerrophos 5 were effective catalysts for the hydrogenation of alkenes and ketones, respectively, producing products with up to 99.7% ee. The analogous palladium complex with 6 worked well for asymmetric allylic alkylation.

引用

页码：5557 / 5560

页数：4

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