Enhancement of norfloxacin solubility via inclusion complexation with β-cyclodextrin and its derivative hydroxypropyl-β-cyclodextrin

被引：85
作者：
Loh, Gabriel Onn Kit [1 ]
Tan, Yvonne Tze Fung [1 ]
Peh, Kok-Khiang [1 ]
机构：
[1] Univ Sains Malaysia, Sch Pharmaceut Sci, Minden 11800, Penang, Malaysia
来源：
ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES | 2016年 / 11卷 / 04期
关键词：
Norfloxacin; Inclusion complexation; Cyclodextrins; Solubility; Dissolution; IMPROVED BIOAVAILABILITY; DISSOLUTION; IMPROVEMENT;
D O I：
10.1016/j.ajps.2016.02.009
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The objectives of the study were to investigate the effects of beta-cyclodextrin (beta CD) and hydroxypropyl-beta-cyclodextrin (HP beta CD) on the solubility and dissolution rate of norfloxacin prepared using three different methods, at drug to cyclodextrin weight ratios of 1: 1, 1: 2, 1: 4 and 1:8. All the methods increased the solubility and dissolution rate of norfloxacin via inclusion complexation with beta CD and HP beta CD. Norfloxacin was converted from crystalline to amorphous form through inclusion complexation. Solvent evaporation method was the most effective method in terms of norfloxacin solubilisation, while inclusion complex of HP beta CD has higher solubility than beta CD complex when prepared using the same procedure. (C) 2016 Production and hosting by Elsevier B.V. on behalf of Shenyang Pharmaceutical University. This is an open access article under the CC BY-NC-ND license
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收藏
页码：536 / 546
页数：11
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