The synergistic effect of fenretinide and metformin to achieve a decrease in insulin resistance and inflammatory mediators: an in vivo study

被引：3
作者：
Hussein, Mohamed M. A. [1 ]
El-Belbasi, Hussein, I [1 ]
Morsy, Mohamed A. [1 ]
Saadeldin, Islam M. [2 ,3 ]
Alshammari, Ghedeir M. [4 ]
机构：
[1] Zagazig Univ, Fac Vet Med, Dept Biochem, Zagazig, Egypt
[2] King Saud Univ, Coll Food & Agr Sci, Dept Anim Prod, Riyadh 11451, Saudi Arabia
[3] Zagazig Univ, Fac Vet Med, Dept Physiol, Zagazig, Egypt
[4] King Saud Univ, Coll Food & Agr Sci, Dept Food Sci & Nutr, Riyadh, Saudi Arabia
来源：
ALL LIFE | 2020年 / 13卷 / 01期
关键词：
Metformin; fenretinide; type; 2; diabetes; insulin resistance; retinol-binding protein 4; inflammatory mediators; BINDING-PROTEIN; 4; TYPE-2; DIABETES-MELLITUS; PROINFLAMMATORY CYTOKINES; GENE-EXPRESSION; TNF-ALPHA; OBESITY; ASSOCIATION; LIVER; IL-6; ADIPOCYTES;
D O I：
10.1080/26895293.2020.1732483
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Background: The effects of metformin and fenretinide on insulin resistance and inflammatory mediators were investigated to treat type 2 diabetes mellitus. Methods: Type 2 diabetes was induced in adult albino Wistar rats via the administration of streptozotocin and nicotinamide. Rats were divided as follows: Group I, control rats administered normal saline solution; Group II, diabetic rats; Group III, diabetic rats treated with metformin; Group IV, diabetic rats administered fenretinide; and Group V, diabetic rats administered both metformin and fenretinide. Results: Fasting blood glucose (FBG) was increased in diabetic rats compared to control rats (p<0.05). However, both FBG and glycated hemoglobin levels were decreased (p<0.05) in diabetic rats treated with fenretinide and metformin compared to diabetic untreated rats. A positive relationship was identified between RBP4 level and insulin resistance. Further, diabetic rats treated with fenretinide and metformin had decreased RBP4 levels. Conversely, GLUT4 mRNA was markedly increased (p<0.05) in diabetic rats administered fenretinide and metformin, thereby improving insulin sensitivity. TNF-alpha level showed a direct relationship with the insulin resistance. Evidently, metformin and fenretinide decreased plasma IL-6 level and increased IL-10 levels. Conclusion: Metformin and fenretinide exhibit individual and synergistic effects when administered to treat diabetes in a rat model.
引用
收藏
页码：108 / 119
页数：12
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