Atypical Progressive Multifocal Leukoencephalopathy in a Patient with Antisynthetase Syndrome

被引：9

作者：

Belhassen-Garcia, Moncef ^{[1
]}

Rabano-Gutierrez, Alberto ^{[2
,3
]}

Velasco-Tirado, Virginia ^{[1
]}

Romero-Alegria, Angela ^{[4
]}

Perez-Garcia, Maria-Luisa ^{[4
]}

Martin-Oterino, Jose Angel ^{[4
]}

机构：

[1] Univ Salamanca, Univ Hosp Salamanca, CIETUS, Dept Internal Med,Unit Infect Dis IBSAL, E-37008 Salamanca, Spain

[2] ISCIII, CIEN Fdn, Res Unit Alzheimer Project, Dept Neuropathol, Madrid, Spain

[3] ISCIII, CIEN Fdn, Res Unit Alzheimer Project, Tissue Bank, Madrid, Spain

[4] Univ Hosp Salamanca, IBSAL, Dept Internal Med, Salamanca, Spain

来源：

INTERNAL MEDICINE | 2015年 / 54卷 / 05期

关键词：

Anti-Jo-1; antisynthetase syndrome; rituximab; progressive multifocal leukoencephalopathy; JC virus; JC VIRUS-DNA; SYSTEMIC-LUPUS-ERYTHEMATOSUS; CENTRAL-NERVOUS-SYSTEM; HIV-NEGATIVE PATIENTS; REFRACTORY POLYMYOSITIS; CEREBROSPINAL-FLUID; RITUXIMAB; THERAPY; EFFICACY; DERMATOMYOSITIS;

D O I：

10.2169/internalmedicine.54.2748

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Antisynthetase syndrome is a disorder belonging to the dermatomyositis/polymyositis group, with high rates of morbidity and mortality. We herein present the case of a 71-year-old man who was diagnosed with antisynthetase syndrome and treated with rituximab. Almost three years later, the patient showed right-sided hemiparesis that ultimately progressed to complete hemiplegia and advancing cognitive deterioration with a poor clinical outcome. The neuropathological diagnosis was progressive multifocal leukoencephalopathy. Treatment with rituximab for antisynthetase syndrome itself plays a fundamental role in the development of infectious complications.

引用

页码：519 / 524

页数：6