Direct C-H Trifluoromethylation of Quinoxalin-2(1H)-ones under Transition-Metal-Free Conditions

被引：127

作者：

Wang, Liping ^{[1
]}

Zhang, Yuecheng ^{[1
,2
]}

Li, Fanfan ^{[1
]}

Hao, Xinyu ^{[1
]}

Zhang, Hong-Yu ^{[1
]}

Zhao, Jiquan ^{[1
]}

机构：

[1] Hebei Univ Technol, Sch Chem Engn & Technol, Tianjin 300130, Peoples R China

[2] Hebei Univ Technol, Natl Local Joint Engn Lab Energy Conservat Chem P, Tianjin 300130, Peoples R China

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2018年 / 360卷 / 20期

基金：

中国国家自然科学基金;

关键词：

C-H Trifluoromethylation; Transition-Metal-Free; Sodium trifluoromethanesulfinate; Quinoxalin-2(1H)-ones; MEDIATED OXIDATIVE TRIFLUOROMETHYLATION; COPPER-CATALYZED TRIFLUOROMETHYLATION; SODIUM TRIFLUOROMETHANESULFINATE; UNACTIVATED ALKENES; LANGLOIS REAGENT; AMINOTRIFLUOROMETHYLATION; OXYTRIFLUOROMETHYLATION; DERIVATIVES; ARYLATION; FUNCTIONALIZATION;

D O I：

10.1002/adsc.201800863

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Disclosed herein is a direct C-H trifluoromethylation of quinoxalin-2(1H)-ones with sodium trifluoromethanesulfinate. This protocol affords a series of 3-trifluoromethylquinoxalin-2(1H)-one derivatives in moderate to excellent yields under transition-metal-free conditions. The present methodology features utilization of the inexpensive trifluoromethyl source without transition-metal-catalysts, mild reaction conditions and high functional group tolerance, which promises a convenient and efficient access to pharmaceutically interesting quinoxalinones.

引用

页码：3969 / 3977

页数：9

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