PGE2-producing MDSC: a role in tumor progression?

被引：29
作者：
Serafini, Paolo [1 ]
机构：
[1] Univ Miami, Dept Microbiol & Immunol, Diabet Res Inst, Sylvester Canc Ctr,Miller Sch Med, Miami, FL 33136 USA
来源：
JOURNAL OF LEUKOCYTE BIOLOGY | 2010年 / 88卷 / 05期
关键词：
COX2; tumor-derived factors; dendritic cells; myeloid-derived suppressor cells; MYELOID SUPPRESSOR-CELLS; DENDRITIC CELLS; T-CELLS; CANCER; DIFFERENTIATION; MECHANISMS; EXPRESSION;
D O I：
10.1189/jlb.0510303
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
引用
收藏
页码：827 / 829
页数：3
相关论文
共 13 条
[1]   Prostaglandin E2 induces FOXP3 gene expression and T regulatory cell function in human CD4+ T cells [J].
Baratelli, F ;
Lin, Y ;
Zhu, L ;
Yang, SC ;
Heuzé-Vourc'h, N ;
Zeng, G ;
Reckamp, K ;
Dohadwala, M ;
Sharma, S ;
Dubinett, SM .
JOURNAL OF IMMUNOLOGY, 2005, 175 (03) :1483-1490
[2]   Tumor-mediated induction of myeloid-derived suppressor cells and M2-polarized macrophages by altering intracellular PGE2 catabolism in myeloid cells [J].
Eruslanov, Evgeniy ;
Daurkin, Irina ;
Ortiz, Javier ;
Vieweg, Johannes ;
Kusmartsev, Sergei .
JOURNAL OF LEUKOCYTE BIOLOGY, 2010, 88 (05) :839-848
[3]   Altered Expression of 15-Hydroxyprostaglandin Dehydrogenase in Tumor-Infiltrated CD11b Myeloid Cells: A Mechanism for Immune Evasion in Cancer [J].
Eruslanov, Evgeniy ;
Kaliberov, Sergei ;
Daurkin, Irina ;
Kaliberova, Lyudmila ;
Buchsbaum, Donald ;
Vieweg, Johannes ;
Kusmartsev, Sergei .
JOURNAL OF IMMUNOLOGY, 2009, 182 (12) :7548-7557
[4]   Mechanisms and functional significance of tumour-induced dendritic-cell defects [J].
Gabrilovich, D .
NATURE REVIEWS IMMUNOLOGY, 2004, 4 (12) :941-952
[5]   The COX-2/PGE2 pathway: key roles in the hallmarks of cancer and adaptation to the tumour microenvironment [J].
Greenhough, Alexander ;
Smartt, Helena J. M. ;
Moore, Amy E. ;
Roberts, Heather R. ;
Williams, Ann C. ;
Paraskeva, Christos ;
Kaidi, Abderrahmane .
CARCINOGENESIS, 2009, 30 (03) :377-386
[6]   Induction of potent antitumor immunity by intratumoral injection of interleukin 23-transduced dendritic cells [J].
Hu, Jinwei ;
Yuan, Xiangpeng ;
Belladonna, Maria L. ;
Ong, John M. ;
Wachsmann-Hogiu, Sebastian ;
Farkas, Daniel L. ;
Black, Keith L. ;
Yu, John S. .
CANCER RESEARCH, 2006, 66 (17) :8887-8896
[7]   Effect of tumor-derived cytokines and growth factors on differentiation and immune suppressive features of myeloid cells in cancer [J].
Kusmartsev, Sergei ;
Gabrilovich, Dmitry I. .
CANCER AND METASTASIS REVIEWS, 2006, 25 (03) :323-331
[8]   Prostaglandin E2 at new glance: Novel insights in functional diversity offer therapeutic chances [J].
Legler, Daniel F. ;
Bruckner, Markus ;
Uetz-von Allmen, Edith ;
Krause, Petra .
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2010, 42 (02) :198-201
[9]   Hyperactivation of STAT3 is involved in abnormal differentiation of dendritic cells in cancer [J].
Nefedova, Y ;
Huang, M ;
Kusmartsev, S ;
Bhattacharya, R ;
Cheng, PY ;
Salup, R ;
Jove, R ;
Gabrilovich, D .
JOURNAL OF IMMUNOLOGY, 2004, 172 (01) :464-474
[10]   Arginase I in myeloid suppressor cells is induced by COX-2 in lung carcinoma [J].
Rodriguez, PC ;
Hernandez, CP ;
Quiceno, D ;
Dubinett, SM ;
Zabaleta, J ;
Ochoa, JB ;
Gilbert, J ;
Ochoa, AC .
JOURNAL OF EXPERIMENTAL MEDICINE, 2005, 202 (07) :931-939
12