A second canon:: Functions and mechanisms of β-catenin-independent wnt signaling

被引：1112
|
作者：
Veeman, MT
Axelrod, JD
Moon, RT [1 ]
机构：
[1] Univ Washington, Sch Med, Howard Hughes Med Inst, Dept Pharmacol,Ctr Dev Biol, Seattle, WA 98195 USA
[2] Univ Washington, Sch Med, Mol & Cellular Biol Program, Seattle, WA 98195 USA
[3] Stanford Univ, Dept Pathol, Sch Med, Stanford, CA 94305 USA
来源：
DEVELOPMENTAL CELL | 2003年 / 5卷 / 03期
关键词：
D O I：
10.1016/S1534-5807(03)00266-1
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
More is becoming known about so-called noncanonical Wnt pathways that signal independently of beta-catenin. Here we review recent developments in both the functions and mechanisms of noncanonical Wnt signaling. We also discuss some unresolved and vexing questions. How many noncanonical Wnt pathways are there? How extensive are the parallels between Drosophila planar polarization and vertebrate convergence and extension? Last, we will outline some challenges and difficulties we foresee for this exciting but still very young field.
引用
收藏
页码：367 / 377
页数：11
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