Membrane budding and scission by the ESCRT machinery: it's all in the neck

被引：576
作者：
Hurley, James H. [1 ]
Hanson, Phyllis I. [2 ]
机构：
[1] NIDDK, Mol Biol Lab, NIH, Bethesda, MD 20892 USA
[2] Washington Univ, Sch Med, Dept Cell Biol & Physiol, St Louis, MO 63110 USA
来源：
NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2010年 / 11卷 / 08期
基金：
美国国家卫生研究院;
关键词：
MULTIVESICULAR BODY PATHWAY; ENDOSOME-ASSOCIATED COMPLEX; AAA ATPASE VPS4; STRUCTURAL BASIS; UBIQUITIN RECOGNITION; SORTING COMPLEX; TRAFFICKING COMPLEX; EAP45-GLUE DOMAIN; VESICLE FORMATION; III RECOGNITION;
D O I：
10.1038/nrm2937
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The endosomal sorting complexes required for transport (ESCRTs) catalyse one of the most unusual membrane remodelling events in cell biology. ESCRT-I and ESCRT-II direct membrane budding away from the cytosol by stabilizing bud necks without coating the buds and without being consumed in the buds. ESCRT-III cleaves the bud necks from their cytosolic faces. ESCRT-III-mediated membrane neck cleavage is crucial for many processes, including the biogenesis of multivesicular bodies, viral budding, cytokinesis and, probably, autophagy. Recent studies of ultrastructures induced by ESCRT-III overexpression in cells and the in vitro reconstitution of the budding and scission reactions have led to breakthroughs in understanding these remarkable membrane reactions.
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收藏
页码：556 / 566
页数：11
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