Site-selective iodine atom transfer in fluorinated alkyl iodides via 1,5-hydrogen atom transfer

被引：2

作者：

Abe, Masahiro ^{[1
]}

Yokoi, Yuka ^{[1
]}

Hirata, Aoi ^{[1
]}

Matsuoka, Yumeno ^{[1
]}

Kimachi, Tetsutaro ^{[1
]}

Inamoto, Kiyofumi ^{[1
]}

机构：

[1] Mukogawa Womens Univ, Sch Pharm & Pharmaceut Sci, 11-68,9 Bancho, Nishinomiya, Hyogo 6638179, Japan

来源：

CHEMICAL COMMUNICATIONS | 2022年 / 58卷 / 53期

关键词：

C-H FUNCTIONALIZATION; BONDS;

D O I：

10.1039/d2cc02803d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The direct and selective functionalization of inert C-H bonds via intramolecular hydrogen atom transfer (HAT) is an increasingly powerful tool in organic synthesis. Herein, we designed an efficient and facile iodine atom transfer in fluorinated alkyl iodides via 1,5-HAT. Our process enables site-selective iodination of unreactive C(sp(3))-H bonds to afford di- and tri-fluorinated alkyl iodides in good yields. Furthermore, our process shows excellent atom economy and high functional group tolerance, including methyl, methoxy, chloro, cyano, and silyl moieties.

引用

页码：7416 / 7418

页数：3

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