Intercellular adhesion molecule 1 antibody-mediated mesoporous drug delivery system for targeted treatment of triple-negative breast cancer

被引：31
作者：
Wang, Mengru [1 ]
Liu, Wanhua [1 ]
Zhang, Yanqiu [2 ]
Dang, Meng [5 ,6 ]
Zhang, Yunlei [3 ]
Tao, Jun [5 ,6 ]
Chen, Kun [5 ,6 ]
Peng, Xin [1 ]
Teng, Zhaogang [3 ,4 ,5 ,6 ]
机构：
[1] Southeast Univ, Sch Med, Jiangsu Key Lab Mol & Funct Imaging, Dept Radiol,Zhongda Hosp, Nanjing 210009, Jiangsu, Peoples R China
[2] Nanjing Univ, Med Sch, Nanjing Drum Tower Hosp, Nanjing 210002, Jiangsu, Peoples R China
[3] Nanjing Univ, Sch Med, Jinling Hosp, Dept Med Imaging, Nanjing 210002, Jiangsu, Peoples R China
[4] Nanjing Univ, Sch Chem & Chem Engn, State Key Lab Analyt Chem Life Sci, Nanjing 210093, Jiangsu, Peoples R China
[5] Nanjing Univ Posts & Telecommun, Key Lab Organ Elect & Informat Displays, Nanjing 210046, Jiangsu, Peoples R China
[6] Nanjing Univ Posts & Telecommun, IAM, Nanjing 210046, Jiangsu, Peoples R China
来源：
JOURNAL OF COLLOID AND INTERFACE SCIENCE | 2019年 / 538卷
基金：
中国国家自然科学基金;
关键词：
Triple-negative breast cancer; Periodic mesoporous organosilica; Drug delivery system; Targeted therapy; ICAM-1; SILICA NANOPARTICLES; THERAPY; GENE; FRAMEWORK; PATTERNS; EFFICACY;
D O I：
10.1016/j.jcis.2018.12.032
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
The development of effective targeted therapies for triple negative breast cancer (TNBC) remains a challenge. This targeted drug delivery system used a near-infrared fluorescence dye cyanine 5.5 (Cy5.5) and an ICAM-1 antibody on thioether-bridged periodic mesoporous organosilica nanoparticles (PMOs). The ICAM-1 antibody and cyanine 5.5-engineered PMOs (PMO-Cy5.5-ICAM) offer excellent in vivo and in vitro biocompatibility. The PMO-Cy5.5-ICAM shows a loading capacity up to 400 mg/g of doxorubicin (DOX). The drug release profile of the DOX-loaded targeted delivery system (DOX@PMO-Cy5.5-ICAM) is pH-sensitive. Confocal microscopy showed that the PMO-Cy5.5-ICAM efficiently targets and enters TNBC cells. In in vivo experiments, the DOX@PMO-Cy5.5-ICAM accumulates more in TNBCs than in the control groups and exhibits better therapeutic effects on TNBC; thus, it is a promising treatment strategy for TNBC. (C) 2018 Elsevier Inc. All rights reserved.
引用
收藏
页码：630 / 637
页数：8
相关论文
共 43 条
  • [21] Drug/Dye-Loaded, Multifunctional PEG-Chitosan-Iron Oxide Nanocomposites for Methotraxate Synergistically Self-Targeted Cancer Therapy and Dual Model Imaging
    Lin, Jinyan
    Li, Yang
    Li, Yanxiu
    Wu, Hongjie
    Yu, Fei
    Zhou, Shuifan
    Xie, Liya
    Luo, Fanghong
    Lin, Changjian
    Hou, Zhenqing
    [J]. ACS APPLIED MATERIALS & INTERFACES, 2015, 7 (22) : 11908 - 11920
  • [22] Smart Cancer Cell Targeting Imaging and Drug Delivery System by Systematically Engineering Periodic Mesoporous Organosilica Nanoparticles
    Lu, Nan
    Tian, Ying
    Tian, Wei
    Huang, Peng
    Liu, Ying
    Tang, Yuxia
    Wang, Chunyan
    Wang, Shouju
    Su, Yunyan
    Zhang, Yunlei
    Pan, Jing
    Teng, Zhaogang
    Lu, Guangming
    [J]. ACS APPLIED MATERIALS & INTERFACES, 2016, 8 (05) : 2985 - 2993
  • [23] Light-Activated Core-Shell Nanoparticles for Spatiotemporally Specific Treatment of Metastatic Triple-Negative Breast Cancer
    Meng, Qingshuo
    Meng, Jia
    Ran, Wei
    Wang, Junyang
    Zhai, Yihui
    Zhang, Pengcheng
    Li, Yaping
    [J]. ACS NANO, 2018, 12 (03) : 2789 - 2802
  • [24] In Situ shRNA Synthesis on DNA-Polylactide Nanoparticles to Treat Multidrug Resistant Breast Cancer
    Ni, Qianqian
    Zhang, Fuwu
    Zhang, Yunlei
    Zhu, Guizhi
    Wang, Zhe
    Teng, Zhaogang
    Wang, Chunyan
    Yung, Bryant C.
    Niu, Gang
    Lu, Guangming
    Zhang, Longjiang
    Chen, Xiaoyuan
    [J]. ADVANCED MATERIALS, 2018, 30 (10)
  • [25] Gold nanorod embedded large-pore mesoporous organosilica nanospheres for gene and photothermal cooperative therapy of triple negative breast cancer
    Ni, Qianqian
    Teng, Zhaogang
    Dang, Meng
    Tian, Ying
    Zhang, Yunlei
    Huang, Peng
    Su, Xiaodan
    Lu, Nan
    Yang, Zhenlu
    Tian, Wei
    Wang, Shouju
    Liu, Wenfei
    Tang, Yuxia
    Lu, Guangming
    Zhang, Longjiang
    [J]. NANOSCALE, 2017, 9 (04) : 1466 - 1474
  • [26] MSN-Mediated Sequential Vascular-to-Cell Nuclear-Targeted Drug Delivery for Efficient Tumor Regression
    Pan, Limin
    Liu, Jianan
    He, Qianjun
    Shi, Jianlin
    [J]. ADVANCED MATERIALS, 2014, 26 (39) : 6742 - 6748
  • [27] Copper-Free Click-Chemistry Platform to Functionalize Cisplatin Prodrugs
    Pathak, Rakesh K.
    McNitt, Christopher D.
    Popik, Vladimir V.
    Dhar, Shanta
    [J]. CHEMISTRY-A EUROPEAN JOURNAL, 2014, 20 (23) : 6861 - 6865
  • [28] Molecular portraits of human breast tumours
    Perou, CM
    Sorlie, T
    Eisen, MB
    van de Rijn, M
    Jeffrey, SS
    Rees, CA
    Pollack, JR
    Ross, DT
    Johnsen, H
    Akslen, LA
    Fluge, O
    Pergamenschikov, A
    Williams, C
    Zhu, SX
    Lonning, PE
    Borresen-Dale, AL
    Brown, PO
    Botstein, D
    [J]. NATURE, 2000, 406 (6797) : 747 - 752
  • [29] Prognostic markers in triple-negative breast cancer
    Rakha, Emad A.
    El-Sayed, Maysa E.
    Green, Andrew R.
    Lee, Andrew H. S.
    Robertson, John F.
    Ellis, Ian O.
    [J]. CANCER, 2007, 109 (01) : 25 - 32
  • [30] Rodler Eve, 2010, Breast Dis, V32, P99, DOI 10.3233/BD-2010-0304
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