Selected variants of the steroid-5-alpha-reductase isoforms SRD5A1 and SRD5A2 and the sex steroid hormone receptors ESR1, ESR2 and PGR: No association with female pattern hair loss identified

被引：19

作者：

Redler, Silke ^{[1
]}

Tazi-Ahnini, Rachid ^{[2
]}

Drichel, Dmitriy ^{[3
]}

Birch, Mary P. ^{[4
]}

Brockschmidt, Felix F. ^{[1
,5
]}

Dobson, Kathy ^{[4
]}

Giehl, Kathrin A. ^{[6
]}

Refke, Melanie ^{[1
]}

Kluck, Nadine ^{[1
,5
]}

Kruse, Roland ^{[7
]}

Lutz, Gerhard ^{[8
]}

Wolff, Hans ^{[6
]}

Boehm, Markus ^{[9
]}

Becker, Tim ^{[3
,10
]}

Noethen, Markus M. ^{[1
,5
]}

Betz, Regina C. ^{[1
]}

Messenger, Andrew ^{[4
]}

机构：

[1] Univ Bonn, Inst Human Genet, D-53127 Bonn, Germany

[2] Univ Sheffield, Dept Infect & Immun, Sheffield, S Yorkshire, England

[3] German Ctr Neurodegenerat Dis DZNE, Bonn, Germany

[4] Royal Hallamshire Hosp, Dept Dermatol, Sheffield S10 2JF, S Yorkshire, England

[5] Univ Bonn, Dept Genom, Life & Brain Ctr, D-53127 Bonn, Germany

[6] Univ Munich, Dept Dermatol, D-8000 Munich, Germany

[7] Dermatol Practice, Paderborn, Germany

[8] Dermatol Practice Hair & Nail, Wesseling, Germany

[9] Univ Munster, Dept Dermatol, D-4400 Munster, Germany

[10] Univ Bonn, Inst Med Biometry Informat & Epidemiol, D-53127 Bonn, Germany

来源：

EXPERIMENTAL DERMATOLOGY | 2012年 / 21卷 / 05期

关键词：

association study; female pattern hair loss; sex steroid hormone receptors; AROMATASE GENE CYP19A1; BREAST-CANCER RISK; ANDROGENETIC ALOPECIA; POLYCYSTIC OVARIES; WIDE ASSOCIATION; HUMAN SKIN; WOMEN; POLYMORPHISMS; PREVALENCE; BALDNESS;

D O I：

10.1111/j.1600-0625.2012.01469.x

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Female pattern hair loss (FPHL) is a common disorder with a complex mode of inheritance. Although understanding of its etiopathogenesis is incomplete, an interaction between genetic and hormonal factors is assumed to be important. The involvement of an androgen-dependent pathway and sex steroid hormones is the most likely hypothesis. We therefore selected a total of 21 variants from the steroid-5-alpha-reductase isoforms SRD5A1 and SRD5A2, the sex steroid hormone receptors ESR1, ESR2 (oestrogen receptor) and PGR (progesterone receptor) and genotyped these in a casecontrol sample of 198 patients (145 UK; 53 German patients) and 329 controls (179 UK; 150 German). None of these variants showed any significant association, either in the overall UK and German samples or in the subgroup analyses. In summary, the present results, while based on a limited selection of gene variants, do not point to the involvement of SRD5A1, SRD5A2, ESR1, ESR2 or PGR in FPHL.

引用

页码：390 / 393

页数：4

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