Cytotoxic and cancer chemopreventive properties of prenylated stilbenoids from Macaranga siamensis

被引：20
|
作者：
Pailee, Phanruethai [1 ]
Sangpetsiripan, Suwannee [1 ]
Mahidol, Chulabhorn [1 ,2 ,3 ]
Ruchirawat, Somsak [1 ,2 ,3 ,4 ]
Prachyawarakorn, Vilailak [1 ]
机构：
[1] Chulabhorn Res Inst, Bangkok 10210, Thailand
[2] Chulabhorn Grad Inst, Bangkok 10210, Thailand
[3] Chem Biol Program, Bangkok 10210, Thailand
[4] Minist Educ, CHE, Ctr Excellence Environm Hlth & Toxicol ENT, Bangkok, Thailand
来源：
TETRAHEDRON | 2015年 / 71卷 / 34期
关键词：
Anticancer; Cancer chemoprevention; Antioxidants; Stilbenoids; Flavonoids; ARTOCARPUS-CHAMA; STEM BARK; LEAVES; RESVERATROL; XANTHONES; TANARIUS; CONSTITUENTS; DERIVATIVES; INHIBITION; AGENTS;
D O I：
10.1016/j.tet.2015.06.058
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Twenty-five new compounds, including macasiamenenes A-U (1-21), a macasiamenin A (22), a macasiamenone A (23), and two macasiamenols A and B (24 and 25), together with five known compounds (26-30) were isolated from the dichloromethane extract of the leaves and twigs of Macaranga siamensis. Their structures were established using spectroscopic techniques. Their cytotoxic and antioxidant properties were evaluated together with their effectiveness as aromatase inhibitors. (C) 2015 Elsevier Ltd. All rights reserved.
引用
收藏
页码：5562 / 5571
页数：10
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