QUANTITATIVE EVALUATION OF JAK2V617F MUTATION AND BCR-ABL P210 TRANSLOCATION IN PATIENTS WITH SIMULTANEOUS JAK2V617F MUTATION AND BCR-ABL TRANSLOCATION

被引：0

作者：

Abdullaev, A. O. ^{[1
]}

Treglazova, S. A. ^{[1
]}

Skorobogatova, A., V ^{[2
]}

Makarik, T., V ^{[1
]}

Stepanova, E. A. ^{[1
]}

Shukhov, O. A. ^{[1
]}

Turkina, A. G. ^{[1
]}

Melikyan, A. L. ^{[1
]}

Kovrigina, A. M. ^{[1
]}

Sudarikov, A. B. ^{[1
]}

机构：

[1] Hematol Res Ctr, Moscow 125167, Russia

[2] Moscow MV Lomonosov State Univ, Moscow 119991, Russia

来源：

GEMATOLOGIYA I TRANSFUZIOLOGIYA | 2015年 / 60卷 / 01期

关键词：

chronic myeloid leukemia; myeloproliferative diseases; JAK2V617F mutation; BCR-ABL p210; real time PCR; JAK2 V617F MUTATION; VERY-LOW LEVEL; ESSENTIAL THROMBOCYTHEMIA; POLYCYTHEMIA-VERA; JAK2(V617F); BLOOD; RARE;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A small number of patients showed simultaneous occurrence of both JAK2(V617F) mutation and BCR/ABL translocation. The problem is whether this simultaneous occurrence of molecular markers indicates the presence of two diseases Ph-negative myeloproliferative disease and Ph-positive myeloproliferative disease. We present two cases of simultaneous occurrence of both JAK2(V617F) mutation and BCR/ABL p210 translocation. Reduction of the BCR-ABL p210 transcript level to 0.29 and 0.014% in cases 1 and 2, respectively, was paralleled by increase of JAK2V617F level to 100% in the former case and its reduction to 5% and subsequent increase to 43% in the latter case.

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页码：29 / 32

页数：4

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