Facile Synthesis of Monodisperse Superparamagnetic Fe3O4 Core@hybrid@Au Shell Nanocomposite for Bimodal Imaging and Photothermal Therapy

被引：273

作者：

Dong, Wenjie ^{[1
]}

Li, Yongsheng ^{[1
]}

Niu, Dechao ^{[1
]}

Ma, Zhi ^{[2
]}

Gu, Jinlou ^{[1
]}

Chen, Yi ^{[3
]}

Zhao, Wenru ^{[1
]}

Liu, Xiaohang ^{[4
]}

Liu, Changsheng ^{[1
]}

Shi, Jianlin ^{[1
,5
]}

机构：

[1] E China Univ Sci & Technol, Sch Mat Sci & Engn, Key Lab Ultrafine Mat, Minist Educ, Shanghai 200237, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Organ Chem, Shanghai 200032, Peoples R China

[3] Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China

[4] Fudan Univ, Dept Radiol, Shanghai Canc Ctr, Shanghai 200032, Peoples R China

[5] Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China

来源：

ADVANCED MATERIALS | 2011年 / 23卷 / 45期

基金：

中国国家自然科学基金;

关键词：

gold nanoshells; superparamagnetic materials; photothermal therapy; magnetic resonance imaging; GOLD NANOSHELLS; THERMAL THERAPY; NANOPARTICLES;

D O I：

10.1002/adma.201103521

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A simple seed-mediated growth route is developed to fabricate monodisperse, uniform superparamagnetic Fe3O4 core/gold shell structured nanocomposites with tunable sizes and optical properties, in which gold seed formation and attachment onto the core surface via S-Au covalent bonding proceeds almost simultaneously in the one-pot synthesis. The as-prepared nanocomposite is demonstrated to have a great potential for magnetic resonance imaging (MRI)-guided, focused photothermal tumor therapy under near-IR laser radiation.

引用

页码：5392 / 5397

页数：6

共 28 条

[1] Tracking of Multimodal Therapeutic Nanocomplexes Targeting Breast Cancer in Vivo [J].

Bardhan, Rizia ;

Chen, Wenxue ;

Bartels, Marc ;

Perez-Torres, Carlos ;

Botero, Maria F. ;

McAninch, Robin Ward ;

Contreras, Alejandro ;

Schiff, Rachel ;

Pautler, Robia G. ;

Halas, Naomi J. ;

Joshi, Amit .

NANO LETTERS, 2010, 10 (12) :4920-4928

[2] Gold nanoparticles in nanomedicine: preparations, imaging, diagnostics, therapies and toxicity [J].

Boisselier, Elodie ;

Astruc, Didier .

CHEMICAL SOCIETY REVIEWS, 2009, 38 (06) :1759-1782

[3] Gold Nanocages as Photothermal Transducers for Cancer Treatment [J].

Chen, Jingyi ;

Glaus, Charles ;

Laforest, Richard ;

Zhang, Qiang ;

Yang, Miaoxian ;

Gidding, Michael ;

Welch, Michael J. ;

Xia, Younan .

SMALL, 2010, 6 (07) :811-817

[4] Plasmonic Nanoshell Synthesis in Microfluidic Composite Foams [J].

Duraiswamy, Suhanya ;

Khan, Saif A. .

NANO LETTERS, 2010, 10 (09) :3757-3763

[5] Surface plasmon resonance scattering and absorption of anti-EGFR antibody conjugated gold nanoparticles in cancer diagnostics: Applications in oral cancer [J].

El-Sayed, IH ;

Huang, XH ;

El-Sayed, MA .

NANO LETTERS, 2005, 5 (05) :829-834

[6]

Habash Riadh W. Y., 2006, Critical Reviews in Biomedical Engineering, V34, P459, DOI 10.1615/CritRevBiomedEng.v34.i6.20

[7] Nanoshell-mediated near-infrared thermal therapy of tumors under magnetic resonance guidance [J].

Hirsch, LR ;

Stafford, RJ ;

Bankson, JA ;

Sershen, SR ;

Rivera, B ;

Price, RE ;

Hazle, JD ;

Halas, NJ ;

West, JL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (23) :13549-13554

[8] Multifunctional Fe3O4@Au Nanoeggs as Photothermal Agents for Selective Killing of Nosocomial and Antibiotic-Resistant Bacteria [J].

Huang, Wei-Chieh ;

Tsai, Pei-Jane ;

Chen, Yu-Chie .

SMALL, 2009, 5 (01) :51-56

[9] Bifunctional gold nanoshells with a superparamagnetic iron oxide-silica core suitable for both MR imaging and photothermal therapy [J].

Ji, Xiaojun ;

Shao, Ruping ;

Elliott, Andrew M. ;

Stafford, R. Jason ;

Esparza-Coss, Emilio ;

Bankson, James A. ;

Liang, Gan ;

Luo, Zhi-Ping ;

Park, Keeseong ;

Markert, John T. ;

Li, Chun .

JOURNAL OF PHYSICAL CHEMISTRY C, 2007, 111 (17) :6245-6251

[10] Gold-Nanoshelled Microcapsules: A Theranostic Agent for Ultrasound Contrast Imaging and Photothermal Therapy [J].

Ke, Hengte ;

Wang, Jinrui ;

Dai, Zhifei ;

Jin, Yushen ;

Qu, Enze ;

Xing, Zhanwen ;

Guo, Caixin ;

Yue, Xiuli ;

Liu, Jibin .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2011, 50 (13) :3017-3021

← 1 2 3 →