Facile Synthesis of Monodisperse Superparamagnetic Fe3O4 Core@hybrid@Au Shell Nanocomposite for Bimodal Imaging and Photothermal Therapy

被引：268

作者：

Dong, Wenjie ^{[1
]}

Li, Yongsheng ^{[1
]}

Niu, Dechao ^{[1
]}

Ma, Zhi ^{[2
]}

Gu, Jinlou ^{[1
]}

Chen, Yi ^{[3
]}

Zhao, Wenru ^{[1
]}

Liu, Xiaohang ^{[4
]}

Liu, Changsheng ^{[1
]}

Shi, Jianlin ^{[1
,5
]}

机构：

[1] E China Univ Sci & Technol, Sch Mat Sci & Engn, Key Lab Ultrafine Mat, Minist Educ, Shanghai 200237, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Organ Chem, Shanghai 200032, Peoples R China

[3] Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China

[4] Fudan Univ, Dept Radiol, Shanghai Canc Ctr, Shanghai 200032, Peoples R China

[5] Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China

来源：

ADVANCED MATERIALS | 2011年 / 23卷 / 45期

基金：

中国国家自然科学基金;

关键词：

gold nanoshells; superparamagnetic materials; photothermal therapy; magnetic resonance imaging; GOLD NANOSHELLS; THERMAL THERAPY; NANOPARTICLES;

D O I：

10.1002/adma.201103521

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A simple seed-mediated growth route is developed to fabricate monodisperse, uniform superparamagnetic Fe3O4 core/gold shell structured nanocomposites with tunable sizes and optical properties, in which gold seed formation and attachment onto the core surface via S-Au covalent bonding proceeds almost simultaneously in the one-pot synthesis. The as-prepared nanocomposite is demonstrated to have a great potential for magnetic resonance imaging (MRI)-guided, focused photothermal tumor therapy under near-IR laser radiation.

引用

页码：5392 / 5397

页数：6

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