β5t-containing thymoproteasome: specific expression in thymic cortical epithelial cells and role in positive selection of CD8+T cells

被引：42

作者：

Takahama, Yousuke ^{[1
]}

Takada, Kensuke ^{[1
]}

Murata, Shigeo ^{[2
]}

Tanaka, Keiji ^{[3
]}

机构：

[1] Univ Tokushima, Inst Genome Res, Div Expt Immunol, Tokushima 7708503, Japan

[2] Univ Tokyo, Grad Sch Pharmaceut Sci, Lab Prot Metab, Tokyo 1130033, Japan

[3] Tokyo Metropolitan Inst Med Sci, Tokyo 1568506, Japan

来源：

CURRENT OPINION IN IMMUNOLOGY | 2012年 / 24卷 / 01期

关键词：

PROTEASOME SUBUNIT BETA-5T; T-CELLS; REPERTOIRE SELECTION; MHC; GENE; MICE; CORTEX; DIFFERENTIATION; FIBROBLASTS; PROGENITOR;

D O I：

10.1016/j.coi.2012.01.006

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Proteasomes are multisubunit proteolytic complexes that degrade cytoplasmic and nuclear proteins in eukaryotes. Proteasome-dependent proteolysis contributes to various cellular processes, including misfolded protein degradation, signal transduction, and antigen presentation. The thymoproteasome is a form of proteasome that contains the vertebrate-specific catalytic subunit beta 5t specifically expressed by cortical epithelial cells in the thymus. The thymoproteasome is essential for the positive selection of CD8+ T cells that carry an immunocompetent repertoire of antigen recognition specificity. Here we summarize the structure and expression of the thymoproteasome and discuss how it regulates the positive selection of CD8+T cells.

引用

页码：92 / 98

页数：7

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