β5t-containing thymoproteasome: specific expression in thymic cortical epithelial cells and role in positive selection of CD8+T cells

被引：41

作者：

Takahama, Yousuke ^{[1
]}

Takada, Kensuke ^{[1
]}

Murata, Shigeo ^{[2
]}

Tanaka, Keiji ^{[3
]}

机构：

[1] Univ Tokushima, Inst Genome Res, Div Expt Immunol, Tokushima 7708503, Japan

[2] Univ Tokyo, Grad Sch Pharmaceut Sci, Lab Prot Metab, Tokyo 1130033, Japan

[3] Tokyo Metropolitan Inst Med Sci, Tokyo 1568506, Japan

来源：

CURRENT OPINION IN IMMUNOLOGY | 2012年 / 24卷 / 01期

关键词：

PROTEASOME SUBUNIT BETA-5T; T-CELLS; REPERTOIRE SELECTION; MHC; GENE; MICE; CORTEX; DIFFERENTIATION; FIBROBLASTS; PROGENITOR;

D O I：

10.1016/j.coi.2012.01.006

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Proteasomes are multisubunit proteolytic complexes that degrade cytoplasmic and nuclear proteins in eukaryotes. Proteasome-dependent proteolysis contributes to various cellular processes, including misfolded protein degradation, signal transduction, and antigen presentation. The thymoproteasome is a form of proteasome that contains the vertebrate-specific catalytic subunit beta 5t specifically expressed by cortical epithelial cells in the thymus. The thymoproteasome is essential for the positive selection of CD8+ T cells that carry an immunocompetent repertoire of antigen recognition specificity. Here we summarize the structure and expression of the thymoproteasome and discuss how it regulates the positive selection of CD8+T cells.

引用

页码：92 / 98

页数：7

共 50 条

[1] Ontogeny of thymic cortical epithelial cells expressing the thymoproteasome subunit β5t
Ripen, Adiratna Mat
Nitta, Takeshi
Murata, Shigeo
Tanaka, Keiji
Takahama, Yousuke
EUROPEAN JOURNAL OF IMMUNOLOGY, 2011, 41 (05) : 1278 - 1287
[2] Restricted Expression of the Thymoproteasome Is Required for Thymic Selection and Peripheral Homeostasis of CD8+ T Cells
Tomaru, Utano
Konno, Saori
Miyajima, Syota
Kimoto, Rikuto
Onodera, Mari
Kiuchi, Shizuka
Murata, Shigeo
Ishizu, Akihiro
Kasahara, Masanori
CELL REPORTS, 2019, 26 (03): : 639 - +
[3] Thymoproteasome optimizes positive selection of CD8+ T cells without contribution of negative selection
Ohigashi, Izumi
Takahama, Yousuke
ADVANCES IN IMMUNOLOGY, VOL 149, 2021, 149 : 1 - 23
[4] The thymoproteasome hardwires the TCR repertoire of CD8+ T cells in the cortex independent of negative selection
Ohigashi, Izumi
Frantzeskakis, Melina
Jacques, Alison
Fujimori, Sayumi
Ushio, Aya
Yamashita, Fusano
Ishimaru, Naozumi
Yin, Da
Cam, Margaret
Kelly, Michael C.
Awasthi, Parirokh
Takada, Kensuke
Takahama, Yousuke
JOURNAL OF EXPERIMENTAL MEDICINE, 2021, 218 (04):
[5] Transcriptome profiling of human thymic CD4+and CD8+T cells compared to primary peripheral T cells
Helgeland, Hanna
Gabrielsen, Ingvild
Akselsen, Helle
Sundaram, Arvind Y. M.
Flam, Siri Tennebo
Lie, Benedicte Alexandra
BMC GENOMICS, 2020, 21 (01) : 1DUMM
[6] Role of thymic cortex-specific self-peptides in positive selection of T cells
Takahama, Yousuke
Nitta, Takeshi
Ripen, Adiratna Mat
Nitta, Sachiko
Murata, Shigeo
Tanaka, Keiji
SEMINARS IN IMMUNOLOGY, 2010, 22 (05) : 287 - 293
[7] Positive selection of self-antigen-specific CD8+ T cells by hematopoietic cells
Yamada, Hisakata
Shibata, Kensuke
Sakuraba, Koji
Fujimura, Kenjiro
Yoshikai, Yasunobu
EUROPEAN JOURNAL OF IMMUNOLOGY, 2013, 43 (08) : 2033 - 2042
[8] Generation of effector CD8+T cells and their conversion to memory T cells
Cui, Weiguo
Kaech, Susan M.
IMMUNOLOGICAL REVIEWS, 2010, 236 : 151 - 166
[9] Low-affinity CD8+T cells provide interclonal help to high-affinity CD8+T cells to augment alloimmunity
Wang, Peter
Chen, Luqiu
Mora-Cartin, Ricardo
McIntosh, Christine M.
Sattar, Husain
Chong, Anita S.
Alegre, Maria-Luisa
AMERICAN JOURNAL OF TRANSPLANTATION, 2024, 24 (06) : 933 - 943
[10] THE THYMIC COMPARTMENT RESPONSIBLE FOR POSITIVE SELECTION OF CD4+ T-CELLS
COSGROVE, D
CHAN, SH
WALTZINGER, C
BENOIST, C
MATHIS, D
INTERNATIONAL IMMUNOLOGY, 1992, 4 (06) : 707 - 710

← 1 2 3 4 5 →