Characterization and Biological Activity of Some New Derivatives Derived from Sulfamethoxazole Compound

被引:15
作者
Alsahib, Sanaa A. [1 ]
机构
[1] Univ Baghdad, Dept Chem, Coll Sci Woman, Baghdad, Iraq
关键词
Biological activity; Characterization; Sulfamethoxazole; Synthesis; COMPLEXES;
D O I
10.21123/bsj.2020.17.2.0471
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
A new series of Sulfamethoxazole derivatives was prepared and examined for antifibrinolytic and antimicrobial activities. Sulfamethoxazole derivatives bear heterocyclic moieties such as 1,3,4-thiadiazine {3}, pyrazolidine-3,5-diol {4} 6-hydroxy-1,3,4-thiadiazinane-2-thione {5} and [(3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-4-yl)diazenyl] {8}. Their structures were elucidated by spectral methods (FT-IR, H-1-NMR). Physical properties are also determined for all compound derivatives. Recently prepared compounds were tested for their antimicrobial activity in the laboratory. Each screened compound showed good tendency to moderate antimicrobial activity.
引用
收藏
页码:471 / 480
页数:10
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