Full range characterization of the Raman spectra of organs in a murine model

被引：110

作者：

Huang, Naiyan ^{[1
,2
,3
,4
]}

Short, Michael ^{[1
]}

Zhao, Jianhua ^{[1
,2
,3
]}

Wang, Hequn ^{[1
,2
,3
]}

Lui, Harvey ^{[1
,2
,3
]}

Korbelik, Mladen ^{[1
]}

Zeng, Haishan ^{[1
,2
,3
]}

机构：

[1] British Columbia Canc Res Ctr, Integrat Oncol Dept, Imaging Unit, Vancouver, BC V5Z 1L3, Canada

[2] Univ British Columbia, Dept Dermatol & Skin Sci, Photomed Inst, Lab Adv Med Photon, Vancouver, BC V5Z 4E8, Canada

[3] Vancouver Coastal Hlth Res Inst, Vancouver, BC V5Z 4E8, Canada

[4] Chinese Peoples Liberat Army Gen Hosp, Dept Laser Med, Beijing, Peoples R China

来源：

OPTICS EXPRESS | 2011年 / 19卷 / 23期

关键词：

IN-VIVO; HUMAN SKIN; BIOCHEMICAL-CHANGES; EPITHELIAL CANCERS; BREAST-TISSUE; BONE TISSUE; MOUSE MODEL; SPECTROSCOPY; SCATTERING; DIAGNOSIS;

D O I：

10.1364/OE.19.022892

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

Raman spectroscopy is a minimally-invasive optical technique with great potential for in vivo cancer detection and disease diagnosis. However, there is no systematic study of the Raman spectra from different organs to date. We measured and characterized the Raman spectra eighteen naive mouse organs in a broad frequency range of 700 to 3100 cm(-1). The peaks of generic proteins and lipids appeared in Raman spectra of all organs. Some organs like bone, teeth, brain and lung had unique Raman peaks. The autofluorescence was strong in liver, spleen, heart, and kidney. These results suggest that organ specific Raman probe design and specific data processing strategies are required in order to get the most useful information. (C) 2011 Optical Society of America

引用

页码：22892 / 22909

页数：18

共 53 条

[1] Study of normal colorectal tissue by FT-Raman spectroscopy [J].