Transforming growth factor-beta 1 induces activation of Ras, Raf-1, MEK and MAPK in rat hepatic stellate cells

被引：88
|
作者：
Reimann, T
Hempel, U
Krautwald, S
Axmann, A
Scheibe, R
Seidel, D
Wenzel, KW
机构：
[1] TECH UNIV DRESDEN,MED FAC CARL GUSTAV CARUS,INST PHYSIOL CHEM,D-01109 DRESDEN,GERMANY
[2] FRAUNHOFER INST TOXICOL & AEROSOL RES,D-30625 HANNOVER,GERMANY
来源：
FEBS LETTERS | 1997年 / 403卷 / 01期
关键词：
transforming growth factor-beta 1; Ras; Raf-1; MEK; MAPK; hepatic stellate cell; signal transduction;
D O I：
10.1016/S0014-5793(97)00024-0
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The transdifferentiation of hepatic stellate cells into myofibroblast-like cells and the proliferation of the transdifferentiated cells are controlled by TGF-beta 1, Little is known about the intracellular signal transducers of TGF-beta 1, In this paper we show that in cultured hepatic stellate cells TGF-beta 1 induces activation of Ras, Raf-1, MEK and MAPK p42 and p44, The activation of MAPK depends on the activation of MEK, Our data exclude that the observed effects are mediated by a bFGF or PDGF autocrine loop. (C) 1997 Federation of European Biochemical Societies.
引用
收藏
页码：57 / 60
页数：4
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