Autonomic dysfunction in presymptomatic spinocerebellar ataxia type-2

被引：23
作者：
Montes-Brown, J. [1 ,2 ]
Machado, A. [3 ]
Estevez, M. [4 ]
Carricarte, C. [3 ]
Velazquez-Perez, L. [2 ]
机构：
[1] Gen Hosp Dr Ernesto Guevara de la Serna, Las Tunas 75100, Cuba
[2] Ctr Res & Rehabil Hereditary Ataxias, Holguin, Cuba
[3] Univ Havana, Fac Biol, Havana, Cuba
[4] Natl Inst Neurol & Neurosurg, Havana, Cuba
来源：
ACTA NEUROLOGICA SCANDINAVICA | 2012年 / 125卷 / 01期
关键词：
autonomic nervous system diseases; heart rate; heart rate variability; parasympathetic; spectral analysis; spinocerebellar ataxias; sympathetic; trinucleotide repeats; FEATURES; DISEASE;
D O I：
10.1111/j.1600-0404.2011.01494.x
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Objectives - To explore and quantify possible abnormalities in the autonomic cardiovascular regulation in presymptomatic stage of type 2 spinocerebellar ataxia (PS-SCA2). Materials & methods - Heart rate variability (HRV) for 5-min series of RR intervals was analyzed in 48 PS-SCA2. Autonomic testing included resting recording, standing, Valsalva maneuver, and deep breathing. The results were compared with a group of sex-and age-matched controls. Results - Time-and-frequency domain HRV indices were significantly different between PS-SCA2 and control groups. Using two standard diagnostic procedures were identified 4 (8.33%) subjects with severe and 8 (16.66%) subjects with early cardiac autonomic neuropathy in PS-SCA2. CAG index significantly correlated with age (-0.35) and HR (0.31). Conclusions Our results confirm the presence of cardiovascular autonomic dysfunction in PS-SCA2 subjects.
引用
收藏
页码：24 / 29
页数：6
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