Autonomic dysfunction in presymptomatic spinocerebellar ataxia type-2

被引：23

作者：

Montes-Brown, J. ^{[1
,2
]}

Machado, A. ^{[3
]}

Estevez, M. ^{[4
]}

Carricarte, C. ^{[3
]}

Velazquez-Perez, L. ^{[2
]}

机构：

[1] Gen Hosp Dr Ernesto Guevara de la Serna, Las Tunas 75100, Cuba

[2] Ctr Res & Rehabil Hereditary Ataxias, Holguin, Cuba

[3] Univ Havana, Fac Biol, Havana, Cuba

[4] Natl Inst Neurol & Neurosurg, Havana, Cuba

来源：

ACTA NEUROLOGICA SCANDINAVICA | 2012年 / 125卷 / 01期

关键词：

autonomic nervous system diseases; heart rate; heart rate variability; parasympathetic; spectral analysis; spinocerebellar ataxias; sympathetic; trinucleotide repeats; FEATURES; DISEASE;

D O I：

10.1111/j.1600-0404.2011.01494.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Objectives - To explore and quantify possible abnormalities in the autonomic cardiovascular regulation in presymptomatic stage of type 2 spinocerebellar ataxia (PS-SCA2). Materials & methods - Heart rate variability (HRV) for 5-min series of RR intervals was analyzed in 48 PS-SCA2. Autonomic testing included resting recording, standing, Valsalva maneuver, and deep breathing. The results were compared with a group of sex-and age-matched controls. Results - Time-and-frequency domain HRV indices were significantly different between PS-SCA2 and control groups. Using two standard diagnostic procedures were identified 4 (8.33%) subjects with severe and 8 (16.66%) subjects with early cardiac autonomic neuropathy in PS-SCA2. CAG index significantly correlated with age (-0.35) and HR (0.31). Conclusions Our results confirm the presence of cardiovascular autonomic dysfunction in PS-SCA2 subjects.

引用

页码：24 / 29

页数：6

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