The Gut Microbiome as a Biomarker of Cancer Progression Among Female Never-smokers With Lung Adenocarcinoma

被引：12

作者：

Otoshi, Takehiro ^{[1
,2
,3
]}

Nagano, Tatsuya ^{[1
]}

Park, Jonguk ^{[4
]}

Hosomi, Koji ^{[2
,3
]}

Yamashita, Tomoya ^{[5
]}

Tachihara, Motoko ^{[1
]}

Tabata, Tokiko ^{[2
,3
,5
]}

Sekiya, Reina ^{[1
]}

Tanaka, Yugo ^{[6
]}

Kobayashi, Kazuyuki ^{[1
]}

Mizuguchi, Kenji ^{[4
,7
]}

Itoh, Tomoo ^{[8
]}

Maniwa, Yoshimasa ^{[6
]}

Kunisawa, Jun ^{[2
,3
]}

Nishimura, Yoshihiro ^{[1
]}

机构：

[1] Kobe Univ, Dept Internal Med, Div Resp Med, Grad Sch Med, Kobe, Hyogo, Japan

[2] Natl Inst Biomed Innovat Hlth & Nutr NIBIOHN, Ctr Vaccine & Adjuvant Res, Lab Vaccine Mat, Ibaraki, Japan

[3] Natl Inst Biomed Innovat Hlth & Nutr NIBIOHN, Lab Gut Environm Syst, Ibaraki, Japan

[4] Natl Inst Biomed Innovat Hlth & Nutr NIBIOHN, Artificial Intelligence Ctr Hlth & Biomed Res, Lab Bioinformat, Ibaraki, Japan

[5] Kobe Univ, Dept Internal Med, Div Cardiovasc Med, Grad Sch Med, Kobe, Hyogo, Japan

[6] Kobe Univ, Div Gen Thorac Surg, Grad Sch Med, Kobe, Hyogo, Japan

[7] Osaka Univ, Inst Prot Res, Suita, Osaka, Japan

[8] Kobe Univ, Dept Diagnost Pathol, Grad Sch Med, Kobe, Hyogo, Japan

来源：

ANTICANCER RESEARCH | 2022年 / 42卷 / 03期

关键词：

Biomarker; gut microbiome; lung adenocarcinoma; never-smokers; FAECALIBACTERIUM-PRAUSNITZII; T-CELLS; DISEASE; RISK;

D O I：

10.21873/anticanres.15633

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background/Aim: The gut microbiome plays an important role in the immune system and has attracted attention as a biomarker of several diseases, including cancer. In this study, we examined the relationship between the gut microbiome and lung cancer progression. Patients and Methods: Female never-smokers diagnosed with lung adenocarcinoma were consecutively enrolled between May 2018 and August 2019, and fecal samples were collected. Principal coordinate analyses were performed using Bray-Curtis distance matrices to investigate the effects of clinical variables (age, body mass index, Tumor-Node-Metastasis stage, T category, N category, M category, primary tumor size, performance status, and EGFR mutation status) on the gut microbial community. Results: A total of 37 patients were enrolled. T category and primary tumor size were significantly correlated with the gut microbial community (p=0.018 and 0.041, respectively). Conclusion: This study identified the gut microbiome as a promising biomarker of lung cancer progression.

引用

页码：1589 / 1598

页数：10

共 37 条

[1] Human Gut Microbiome and Risk for Colorectal Cancer [J].

Ahn, Jiyoung ;

Sinha, Rashmi ;

Pei, Zhiheng ;

Dominianni, Christine ;

Wu, Jing ;

Shi, Jianxin ;

Goedert, James J. ;

Hayes, Richard B. ;

Yang, Liying .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2013, 105 (24) :1907-1911

[2] Desired Turbulence? Gut-Lung Axis, Immunity, and Lung Cancer [J].

Bingula, Rea ;

Filaire, Marc ;

Radosevic-Robin, Nina ;

Bey, Mathieu ;

Berthon, Jean-Yves ;

Bernalier-Donadille, Annick ;

Vasson, Marie-Paule ;

Filaire, Edith .

JOURNAL OF ONCOLOGY, 2017, 2017

[3] Enterococcus faecalis Enhances Cell Proliferation through Hydrogen Peroxide-Mediated Epidermal Growth Factor Receptor Activation [J].

Boonanantanasarn, Kanitsak ;

Gill, Ann Lindley ;

Yap, YoonSing ;

Jayaprakash, Vijayvel ;

Sullivan, Maureen A. ;

Gill, Steven R. .

INFECTION AND IMMUNITY, 2012, 80 (10) :3545-3558

[4] Emerging pathogenic links between microbiota and the gut-lung axis [J].

Budden, Kurtis F. ;

Gellatly, Shaan L. ;

Wood, David L. A. ;

Cooper, Matthew A. ;

Morrison, Mark ;

Hugenholtz, Philip ;

Hansbro, Philip M. .

NATURE REVIEWS MICROBIOLOGY, 2017, 15 (01) :55-63

[5] Colorectal cancer mutational profiles correlate with defined microbial communities in the tumor microenvironment [J].

Burns, Michael B. ;

Montassier, Emmanuel ;

Abrahante, Juan ;

Priya, Sambhawa ;

Niccum, David E. ;

Khoruts, Alexander ;

Starr, Timothy K. ;

Knights, Dan ;

Blekhman, Ran .

PLOS GENETICS, 2018, 14 (06)

[6] QIIME allows analysis of high-throughput community sequencing data [J].

Caporaso, J. Gregory ;

Kuczynski, Justin ;

Stombaugh, Jesse ;

Bittinger, Kyle ;

Bushman, Frederic D. ;

Costello, Elizabeth K. ;

Fierer, Noah ;

Pena, Antonio Gonzalez ;

Goodrich, Julia K. ;

Gordon, Jeffrey I. ;

Huttley, Gavin A. ;

Kelley, Scott T. ;

Knights, Dan ;

Koenig, Jeremy E. ;

Ley, Ruth E. ;

Lozupone, Catherine A. ;

McDonald, Daniel ;

Muegge, Brian D. ;

Pirrung, Meg ;

Reeder, Jens ;

Sevinsky, Joel R. ;

Tumbaugh, Peter J. ;

Walters, William A. ;

Widmann, Jeremy ;

Yatsunenko, Tanya ;

Zaneveld, Jesse ;

Knight, Rob .

NATURE METHODS, 2010, 7 (05) :335-336

[7] Microbiota dysbiosis in select human cancers: Evidence of association and causality [J].

Chen, Jie ;

Domingue, Jada C. ;

Sears, Cynthia L. .

SEMINARS IN IMMUNOLOGY, 2017, 32 (0C) :25-34

[8] Search and clustering orders of magnitude faster than BLAST [J].

Edgar, Robert C. .

BIOINFORMATICS, 2010, 26 (19) :2460-2461

[9]

Gansler T, 2010, CA-CANCER J CLIN, V60, P1, DOI [10.3322/caac.20049, 10.3322/caac.20073]

[10] Gut microbiota and colorectal cancer [J].

Gao, R. ;

Gao, Z. ;

Huang, L. ;

Qin, H. .

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 2017, 36 (05) :757-769

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