Anti-allergic inflammatory effects of hepatocyte growth factor

被引：12

作者：

Ito, Wataru ^{[1
]}

Takeda, Masahide ^{[1
]}

Tanabe, Masako ^{[1
]}

Kihara, Junko ^{[1
]}

Kato, Hikari ^{[1
]}

Chiba, Takahito ^{[1
]}

Yamaguchi, Kazutoshi ^{[1
]}

Ueki, Shigeharu ^{[1
]}

Kanehiro, Arihiko ^{[2
]}

Kayaba, Hiroyuki ^{[1
]}

Chihara, Junichi ^{[1
]}

机构：

[1] Akita Univ, Sch Med, Dept Clin & Lab Med, Akita 0108543, Japan

[2] Okayama Univ, Grad Sch Med & Dent, Dept Hematol Oncol & Resp Med, Okayama, Japan

来源：

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY | 2008年 / 146卷

关键词：

hepatocyte growth factor; eosinophil; allergy; asthma;

D O I：

10.1159/000126067

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Hepatocyte growth factor (HGF) is known to influence a number of cell types and regulate various biological activities including cytokine production, cell migration, proliferation and survival. Thus, HGF is now recognized to be a key factor in the prevention and attenuation of disease progression. We have reported that HGF reduces allergic airway inflammation, airway hyperresponsiveness, remodeling and development of Th2 cytokines as well as growth factors such as transforming growth factor-beta in vivo. In vitro, HGF directly attenuates chemotaxis of eosinophils in the absence of Th2 cytokines and modulates mitogen-activated protein kinases, which play an important role in eosinophil migration. In this review, we discuss the physiological role of HGF in allergic inflammation and its mechanism of anti-inflammatory effects, including the regulation of eosinophil functions. Copyright (C) 2008 S. Karger AG, Basel.

引用

页码：82 / 87

页数：6

共 49 条

[1] The functional role of Rho and Rho-associated coiled-coil forming protein kinase in eotaxin signaling of eosinophils [J].

Adachi, T ;

Vita, R ;

Sannohe, S ;

Stafford, S ;

Alam, R ;

Kayaba, H ;

Chihara, J .

JOURNAL OF IMMUNOLOGY, 2001, 167 (08) :4609-4615

[2] IDENTIFICATION OF ACTIVATED LYMPHOCYTES-T AND EOSINOPHILS IN BRONCHIAL BIOPSIES IN STABLE ATOPIC ASTHMA [J].

AZZAWI, M ;

BRADLEY, B ;

JEFFERY, PK ;

FREW, AJ ;

WARDLAW, AJ ;

KNOWLES, G ;

ASSOUFI, B ;

COLLINS, JV ;

DURHAM, S ;

KAY, AB .

AMERICAN REVIEW OF RESPIRATORY DISEASE, 1990, 142 (06) :1407-1413

[3] INOSITOL TRISPHOSPHATE AND CALCIUM SIGNALING [J].

BERRIDGE, MJ .

NATURE, 1993, 361 (6410) :315-325

[4] HGF attenuates thrombin-induced endothelial permeability by Tiam1-mediated activation of the Rac pathway and by Tiam1/Rac-dependent inhibition of the Rho pathway [J].

Birukova, Anna A. ;

Alekseeva, Elena ;

Mikaelyan, Arsen ;

Birukov, Konstantin G. .

FASEB JOURNAL, 2007, 21 (11) :2776-2786

[5]

Boehme SA, 1999, J IMMUNOL, V163, P1611

[6] Nerve growth factor: An important molecule in allergic inflammation and tissue remodelling [J].

Bonini, S ;

Lambiase, A ;

Bonini, S ;

Levi-Schaffer, F ;

Aloe, L .

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 1999, 118 (2-4) :159-162

[7] Effect of local application of growth factors on gastric ulcer healing and mucosal expression of cyclooxygenase-1 and-2 [J].

Brzozowski, T ;

Konturek, PC ;

Konturek, SJ ;

Schuppan, D ;

Drozdowicz, D ;

Kwiecien, S ;

Majka, J ;

Nakamura, T ;

Hahn, EG .

DIGESTION, 2001, 64 (01) :15-29

[8] Hepatocyte growth factor preserves beta cell mass and mitigates hyperglycemia in streptozotocin-induced diabetic mice [J].

Dai, CS ;

Li, YJ ;

Yang, JW ;

Liu, YH .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (29) :27080-27087

[9] Airway remodeling in asthma [J].

Elias, JA ;

Zhu, Z ;

Chupp, G ;

Homer, RJ .

JOURNAL OF CLINICAL INVESTIGATION, 1999, 104 (08) :1001-1006

[10] Allergen-specific Th1 cells fail to counterbalance Th2 cell-induced airway hyperreactivity but cause severe airway inflammation [J].

Hansen, G ;

Berry, G ;

DeKruyff, RH ;

Umetsu, DT .

JOURNAL OF CLINICAL INVESTIGATION, 1999, 103 (02) :175-183

← 1 2 3 4 5 →