Addressing screams for evidence on renoprotection by GLP-1 receptor agonists

被引：4

作者：

Sasako, Takayoshi ^{[1
]}

Yamauchi, Toshimasa ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Med, Dept Diabet & Metab Dis, Tokyo, Japan

来源：

KIDNEY INTERNATIONAL | 2022年 / 101卷 / 02期

关键词：

KIDNEY OUTCOMES; SGLT2; INHIBITORS; RISK;

D O I：

10.1016/j.kint.2021.11.021

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Although growing evidence supports the benefits of glucagon-like peptide-1 receptor agonists, the renoprotective effects were not fully proven in clinical trials. Now, Xu et al. show that glucagon-like peptide 1 receptor agonists reduce the renal outcome compared with dipeptidyl peptidase-4 inhibitors in a retrospective cohort study of the participants in the Stockholm Creatinine Measurements project undertaken in Stockholm, Sweden. Despite some limitations, the study shows renoprotection by glucagon-like peptide-1 receptor agonists and raises hope about upcoming evidence from prospective clinical trials. Copyright (C) 2021, International Society of Nephrology. Published by Elsevier Inc. All rights reserved.

引用

页码：222 / 224

页数：3

共 8 条

[1]

Heerspink HJL, 2020, LANCET DIABETES ENDO, V8, P27, DOI 10.1016/S2213-8587(19)30384-5

[2] Kidney Outcomes Associated With SGLT2 Inhibitors Versus Other Glucose-Lowering Drugs in Real-world Clinical Practice: The Japan Chronic Kidney Disease Database [J].

Nagasu, Hajime ;

Yano, Yuichiro ;

Kanegae, Hiroshi ;

Heerspink, Hiddo J. L. ;

Nangaku, Masaomi ;

Hirakawa, Yosuke ;

Sugawara, Yuka ;

Nakagawa, Naoki ;

Tani, Yuji ;

Wada, Jun ;

Sugiyama, Hitoshi ;

Tsuruya, Kazuhiko ;

Nakano, Toshiaki ;

Maruyama, Shoichi ;

Wada, Takashi ;

Yamagata, Kunihiro ;

Narita, Ichiei ;

Tamura, Kouichi ;

Yanagita, Motoko ;

Terada, Yoshio ;

Shigematsu, Takashi ;

Sofue, Tadashi ;

Ito, Takafumi ;

Okada, Hirokazu ;

Nakashima, Naoki ;

Kataoka, Hiromi ;

Ohe, Kazuhiko ;

Okada, Mihoko ;

Itano, Seiji ;

Nishiyama, Akira ;

Kanda, Eiichiro ;

Ueki, Kohjiro ;

Kashihara, Naoki .

DIABETES CARE, 2021, 44 (11) :2542-2551

[3] Use of Glucagon-Like Peptide 1 Receptor Agonists and Risk of Serious Renal Events: Scandinavian Cohort Study [J].

Pasternak, Bjorn ;

Wintzell, Viktor ;

Eliasson, Bjorn ;

Svensson, Ann-Marie ;

Franzen, Stefan ;

Gudbjornsdottir, Soffia ;

Hveem, Kristian ;

Jonasson, Christian ;

Melbye, Mads ;

Svanstrom, Henrik ;

Ueda, Peter .

DIABETES CARE, 2020, 43 (06) :1326-1335

[4] The Stockholm CREAtinine Measurements (SCREAM) project: protocol overview and regional representativeness [J].

Runesson, Bjorn ;

Gasparini, Alessandro ;

Qureshi, Abdul Rashid ;

Norin, Olof ;

Evans, Marie ;

Barany, Peter ;

Wettermark, Bjorn ;

Elinder, Carl Gustaf ;

Carrero, Juan Jesus .

CLINICAL KIDNEY JOURNAL, 2016, 9 (01) :119-127

[5] Cardiovascular, mortality, and kidney outcomes with GLP-1 receptor agonists in patients with type 2 diabetes: a systematic review and meta-analysis of randomised trials [J].

Sattar, Naveed ;

Lee, Matthew M. Y. ;

Kristensen, Soren L. ;

Branch, Kelley R. H. ;

Del Prato, Stefano ;

Khurmi, Nardev S. ;

Lam, Carolyn S. P. ;

Lopes, Renato D. ;

McMurray, John J., V ;

Pratley, Richard E. ;

Rosenstock, Julio ;

Gerstein, Hertzel C. .

LANCET DIABETES & ENDOCRINOLOGY, 2021, 9 (10) :653-662

[6] Multifactorial intervention has a significant effect on diabetic kidney disease in patients with type 2 diabetes [J].

Ueki, Kohjiro ;

Sasako, Takayoshi ;

Okazaki, Yukiko ;

Miyake, Kana ;

Nangaku, Masaomi ;

Ohashi, Yasuo ;

Noda, Mitsuhiko ;

Kadowaki, Takashi .

KIDNEY INTERNATIONAL, 2021, 99 (01) :256-266

[7] Comparative Effectiveness of SGLT2 Inhibitors, GLP-1 Receptor Agonists, DPP-4 Inhibitors, and Sulfonylureas on Risk of Kidney Outcomes: Emulation of a Target Trial Using Health Care Databases [J].

Xie, Yan ;

Bowe, Benjamin ;

Gibson, Andrew K. ;

McGill, Janet B. ;

Maddukuri, Geetha ;

Yan, Yan ;

Al-Aly, Ziyad .

DIABETES CARE, 2020, 43 (11) :2859-2869

[8] GLP-1 receptor agonist versus DPP-4 inhibitor and kidney and cardiovascular outcomes in clinical practice in type-2 diabetes [J].

Xu, Yang ;

Fu, Edouard L. ;

Clase, Catherine M. ;

Mazhar, Faizan ;

Jardine, Meg J. ;

Carrero, Juan J. .

KIDNEY INTERNATIONAL, 2022, 101 (02) :360-368

← 1 →