Three-dimensional changes of noses after transplantation of implant-type tissue-engineered cartilage for secondary correction of cleft lipenose patients

被引：26

作者：

Hoshi, Kazuto ^{[1
,2
]}

Fujihara, Yuko ^{[1
]}

Saijo, Hideto ^{[1
]}

Kurabayashi, Kumiko ^{[1
]}

Suenaga, Hideyuki ^{[1
]}

Asawa, Yukiyo ^{[2
]}

Nishizawa, Satoru ^{[3
]}

Kanazawa, Sanshiro ^{[2
]}

Uto, Sakura ^{[2
]}

Inaki, Ryoko ^{[2
]}

Matsuyama, Mariko ^{[2
]}

Sakamoto, Tomoaki ^{[2
]}

Watanabe, Makoto ^{[2
]}

Sugiyama, Madoka ^{[1
]}

Yonenaga, Kazumichi ^{[1
]}

Hikita, Atsuhiko ^{[2
]}

Takato, Tsuyoshi ^{[1
,2
]}

机构：

[1] Univ Tokyo, Grad Sch Med, Dept Sensory & Motor Syst Med, Oral & Maxillofacial Surg,Bunkyo Ku, Hongo 7-3-1, Tokyo 1138655, Japan

[2] Univ Tokyo Hosp, Div Tissue Engn, Bunkyo Ku, Hongo 7-3-1, Tokyo 1138655, Japan

[3] Univ Tokyo Hosp, Translat Res Ctr, Hongo 7-3-1, Tokyo 1138655, Japan

来源：

REGENERATIVE THERAPY | 2017年 / 7卷

关键词：

Tissue engineering; Cartilage; Cleft lip and palate; Nose; Three dimension; RHINOPLASTY; DEFECTS; BONE; LIP; SCAFFOLDS; GRAFTS; REPAIR; KNEES;

D O I：

10.1016/j.reth.2017.09.001

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Introduction: We have developed an implant-type tissue-engineered cartilage using a poly-L-lactide scaffold. In a clinical study, it was inserted into subcutaneous areas of nasal dorsum in three patients, to correct cleft lipenose deformity. The aim of this study was to helping evaluation on the efficacy of the regenerative cartilage. Methods: 3D data of nasal shapes were compared between before and after surgery in computed tomography (CT) images. Morphological and qualitative changes of transplants in the body were also evaluated on MRI, for one year. Results: The 3D data from CT images showed effective augmentation (> 2 mm) of nasal dorsum in almost whole length, observed on the medial line of faces. It was maintained by 1 year post-surgery in all patients, while affected curves of nasal dorsum was not detected throughout the observation period. In magnetic resonance imaging (MRI), the images of transplanted cartilage had been observed until 1 year post-surgery. Those images were seemingly not straight when viewed from the longitudinal plain, and may have shown gentle adaptation to the surrounding nasal bones and alar cartilage tissues. Conclusion: Those findings suggested the potential efficacy of this cartilage on improvement of cleft lip enose deformity. A clinical trial is now being performed for industrialization. (C) 2017, The Japanese Society for Regenerative Medicine. Production and hosting by Elsevier B.V.

引用

页码：72 / 79

页数：8

共 18 条

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[2]

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