MicroRNA: Potential biomarker and target of therapy in acute lung injury

被引：26
作者：
Jiang, Z-F [1 ,2 ]
Zhang, L. [1 ,2 ]
Shen, J. [1 ,2 ]
机构：
[1] Fudan Univ, Jinshan Hosp, Ctr Emergency, Shanghai 200433, Peoples R China
[2] Fudan Univ, Jinshan Hosp, Intens Care Unit, Med Ctr Chem Injury, Shanghai 200433, Peoples R China
来源：
HUMAN & EXPERIMENTAL TOXICOLOGY | 2020年 / 39卷 / 11期
基金：
中国国家自然科学基金;
关键词：
miRNA; acute lung injury; biomarker; therapy; RESPIRATORY-DISTRESS-SYNDROME; MODULATES MACROPHAGE POLARIZATION; CIRCULATING MICRORNAS; INDUCED INFLAMMATION; MIRNA THERAPEUTICS; PROTECTS MICE; IN-VIVO; KAPPA-B; EXPRESSION; APOPTOSIS;
D O I：
10.1177/0960327120926254
中图分类号：
R99 [毒物学（毒理学）];
学科分类号：
100405 ;
摘要：
MicroRNAs (miRNAs) are small noncoding RNAs stretching over 18-22 nucleotides and considered to be modifiers of many respiratory diseases. They are highly evolutionary conserved and have been implicated in several biological processes, including cell proliferation, apoptosis, differentiation, among others. Acute lung injury (ALI) is a fatal disease commonly caused by direct or indirect injury factors and has a high mortality rate in intensive care unit. Changes in expression of several types of miRNAs have been reported in patients with ALI. Some miRNAs suppress cellular injury and accelerate the recovery of ALI by targeting specific molecules and decreasing excessive immune response. For this reason, miRNAs are proposed as potential biomarkers for ALI and as therapeutic targets for this disease. This review summarizes current evidence supporting the role of miRNAs in ALI.
引用
收藏
页码：1429 / 1442
页数：14
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