Halofuginone may suppresses azoxymethane-induced serum tumor necrosis factor-a synthesis and aberrant crypt foci progression in rat colon

被引:2
|
作者
Corum, Orhan [1 ]
Ozdemir, Ozgur [1 ,2 ]
Yazar, Enver [1 ,3 ]
机构
[1] Dicle Univ, Vet Fac, Dept Pharmacol & Toxicol, TR-21280 Diyarbakir, Turkey
[2] Selcuk Univ, Vet Fac, Dept Pharmacol & Toxicol, TR-42075 Konya, Turkey
[3] Selcuk Univ, Vet Fac, Dept Pathol, TR-42075 Konya, Turkey
关键词
Aberrant crypt foci; Colon cancer; Cytokines; Halofuginone; NF-KAPPA-B; CANCER; INHIBITION; GROWTH; ANGIOGENESIS; MICE;
D O I
10.18805/ijar.v0i0f.7600
中图分类号
S8 [畜牧、 动物医学、狩猎、蚕、蜂];
学科分类号
0905 ;
摘要
The aim of this research was to investigate the effect of halofuginone on the progression of azoxymethane-induced colon cancer in rats. A total of 38 male Wistar albino rats were divided into 4 groups: Control (n=8), Halofuginone (n= 10, 0.4 mg/kg, PO, SID), Cancer (n=10, azoxymethane, 15 mg/kg, IP, once a week for two weeks) and Cancer + Halofuginone (n=10). After 18 weeks, blood samples were taken under anesthesia and all animals were sacrificed. Aberrant crypt foci in the colon were stained with methylene blue. Blood cytokines, thiobarbituric acid reactive substances, 13,14-dihydro-15-ketoprostaglandin F2 alpha levels, hemogram and biochemical values were measured. The tumor necrosis factor-a level in the Cancer group was higher (P<0.05) than in other groups, while higher numbers of aberrant crypt foci were found in the Cancer group compared with the Cancer + Halofuginone group (P<0.05). In summary, it may be stated that halofuginone may warrant evaluation as a supportive drug in the treatment of colon cancer in the future.
引用
收藏
页码:1120 / 1124
页数:5
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