A systematic review of anti-cancer roles and mechanisms of kaempferol as a natural compound

被引:46
作者
Amjad, Elham [1 ]
Sokouti, Babak [1 ]
Asnaashari, Solmaz [1 ]
机构
[1] Tabriz Univ Med Sci, Biotechnol Res Ctr, Tabriz, Iran
关键词
Anti-cancer; Natural compounds; Kaempferol; Mechanisms; Signaling pathways; CELL-CYCLE ARREST; FASTING PLASMA-CONCENTRATIONS; ENDOPLASMIC-RETICULUM STRESS; RECEPTOR-ALPHA EXPRESSION; ARYL-HYDROCARBON RECEPTOR; OVARIAN-CANCER CELLS; DOWN-REGULATION; LUNG-CANCER; HEPATOCELLULAR-CARCINOMA; IN-VITRO;
D O I
10.1186/s12935-022-02673-0
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
It has been shown in multiple experimental and biological investigations that kaempferol, an edible flavonoid generated from plants, may be used as an anti-cancer drug and has been shown to have anti-cancer properties. Many signaling pathways are altered in cancer cells, resulting in cell growth inhibition and death in various tumor types. Cancer is a multifaceted illness coordinated by multiple external and internal mechanisms. Natural extracts with the fewest side effects have piqued the attention of researchers in recent years, attempting to create cancer medicines based on them. An extensive array of natural product-derived anti-cancer agents have been examined to find a successful method. Numerous fruits and vegetables have high levels of naturally occurring flavonoid kaempferol, and its pharmacological and biological effects have been studied extensively. Certain forms of cancer are sensitive to kaempferol-mediated anti-cancer activity, although complete research is needed. We have endeavored to concentrate our review on controlling carcinogenic pathways by kaempferol in different malignancies. Aside from its extraordinary ability to modify cell processes, we have also discussed how kaempferol has the potential to be an effective therapy for numerous tumors.
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页数:22
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共 135 条
[1]   IRE1 is critical for Kaempferol-induced neuroblastoma differentiation [J].
Abdullah, Ahmad ;
Talwar, Priti ;
d'Hellencourt, Christian Lefebvre ;
Ravanan, Palaniyandi .
FEBS JOURNAL, 2019, 286 (07) :1375-1392
[2]   Formulation of Kaempferol in Nanostructured Lipid Carriers (NLCs): A Delivery Platform to Sensitization of MDA-MB468 Breast Cancer Cells to Paclitaxel [J].
Aghazadeh, Toofan ;
Bakhtiari, Nuredin ;
Rad, Isa Abdi ;
Ramezani, Fatemeh .
BIOINTERFACE RESEARCH IN APPLIED CHEMISTRY, 2021, 11 (06) :14591-14601
[3]   A Novel Hybrid Convolutional Neural Network Approach for the Stomach Intestinal Early Detection Cancer Subtype Classification [J].
Ahmed, Md Ezaz .
COMPUTATIONAL INTELLIGENCE AND NEUROSCIENCE, 2022, 2022
[4]   Kaempferol as a Dietary Anti-Inflammatory Agent: Current Therapeutic Standing [J].
Alam, Waqas ;
Khan, Haroon ;
Shah, Muhammad Ajmal ;
Cauli, Omar ;
Saso, Luciano .
MOLECULES, 2020, 25 (18)
[5]   An investigation of 6-Shogaol effects on MCF7 cell lines through a systems biology approach [J].
Amjad, Elham ;
Sokouti, Babak ;
Asnaashari, Solmaz .
EGYPTIAN JOURNAL OF MEDICAL HUMAN GENETICS, 2022, 23 (01)
[6]   Impact of Gene Biomarker Discovery Tools Based on Protein-Protein Interaction and Machine Learning on Performance of Artificial Intelligence Models in Predicting Clinical Stages of Breast Cancer [J].
Amjad, Elham ;
Asnaashari, Solmaz ;
Sokouti, Babak ;
Dastmalchi, Siavoush .
INTERDISCIPLINARY SCIENCES-COMPUTATIONAL LIFE SCIENCES, 2020, 12 (04) :476-486
[7]   Systems biology comprehensive analysis on breast cancer for identification of key gene modules and genes associated with TNM-based clinical stages [J].
Amjad, Elham ;
Asnaashari, Solmaz ;
Sokouti, Babak ;
Dastmalchi, Siavoush .
SCIENTIFIC REPORTS, 2020, 10 (01)
[8]   Kaempferol, a tea flavonol, effect on interleukin-2 signal transduction of human T cell leukemia [J].
Asai, K ;
Moriwaki, S ;
Maeda-Yamamoto, M .
JARQ-JAPAN AGRICULTURAL RESEARCH QUARTERLY, 2005, 39 (03) :175-179
[9]   Understanding the Effectiveness of Natural Compound Mixtures in Cancer through Their Molecular Mode of Action [J].
Aung, Thazin Nwe ;
Qu, Zhipeng ;
Kortschak, R. Daniel ;
Adelson, David L. .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2017, 18 (03)
[10]   The Chemopreventive Effect of the Dietary Compound Kaempferol on the MCF-7 Human Breast Cancer Cell Line Is Dependent on Inhibition of Glucose Cellular Uptake [J].
Azevedo, Claudia ;
Correia-Branco, Ana ;
Araujo, Joao R. ;
Guimaraes, Joao T. ;
Keating, Elisa ;
Martel, Fatima .
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL, 2015, 67 (03) :504-513