Diagnostic values of thyroglobulin measurement in fine-needle aspiration of lymph nodes in patients with thyroid cancer

被引：35

作者：

Pak, Kyoungjune ^{[1
,2
]}

Suh, Sunghwan ^{[3
]}

Hong, Hyunsook ^{[4
]}

Cheon, Gi Jeong ^{[1
,5
]}

Hahn, Seo Kyung ^{[4
]}

Kang, Keon Wook ^{[1
,5
]}

Kim, E. Edmund ^{[6
,7
]}

Lee, Dong Soo ^{[1
,5
,6
]}

Chung, June-Key ^{[1
,5
]}

机构：

[1] Seoul Natl Univ, Dept Nucl Med, Coll Med, Seoul 110744, South Korea

[2] Pusan Natl Univ Hosp, Dept Nucl Med, Busan 602739, South Korea

[3] Dong A Univ, Coll Med, Dept Internal Med, Busan, South Korea

[4] Seoul Natl Univ, Med Res Collaborating Ctr, Coll Med, Seoul 110744, South Korea

[5] Seoul Natl Univ, Canc Res Inst, Coll Med, Seoul 110744, South Korea

[6] Seoul Natl Univ, WCU Grad Sch Concergence Sci & Technol, Coll Med, Seoul 110744, South Korea

[7] Univ Calif Irvine, Dept Radiol Sci, Irvine, CA 92717 USA

来源：

ENDOCRINE | 2015年 / 49卷 / 01期

基金：

新加坡国家研究基金会;

关键词：

Thyroid cancer; Biopsy; Fine-needle; Thyroglobulin; WASHOUT FLUID; TG MEASUREMENT; BIOPSY; METASTASES; LESIONS; MASSES; CLUE;

D O I：

10.1007/s12020-014-0410-z

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We aimed to evaluate the diagnostic performance of measuring the concentration of thyroglobulin (Tg) in the washout fluid of the needle aspiration (FNATg). We performed a systematic search of MEDLINE (inception to October 2013) and EMBASE (inception to October 2013) for English publications using keywords "thyroid'', "aspiration'', "washout'', and "thyroglobulin''. All searches were limited to human studies. We included studies of FNA-Tg measurement in the washout fluid rinsed with 1 ml of normal saline. Eight studies including 843 lymph nodes (LNs) were eligible for this study. The pooled sensitivity and specificity of preoperative studies are 0.89 [95 % CI 0.82-0.95], 0.60 [0.49-0.70], and those of postoperative studies are 1.0 [0.83-1.0], 1.0 [0.92-1.0]. To determine best cutoffs from each preoperative and postoperative study, the distance between the point (0, 1) and each observed cutoff values (1-specificity, sensitivity) was calculated, and the distance is minimal when the cutoff value of 32.04 for preoperative studies and of 0.9 for postoperative one are selected. FNA-Tg can be used for both preoperative and postoperative evaluation of LN metastasis. Although the cutoff values for the FNA-Tg has not been standardized, preoperative values of 32.04 ng/ml and postoperative values of 0.9 ng/ml are recommended for identifying neck LN metastasis

引用

页码：70 / 77

页数：8

共 34 条

[1] The diagnostic value for differentiated thyroid carcinoma metastases of thyroglobulin (Tg) measurement in washout fluid from fine-needle aspiration biopsy of neck lymph nodes is maintained in the presence of circulating anti-Tg antibodies [J].