Role of Serum Amyloid A in Abdominal Aortic Aneurysm and Related Cardiovascular Diseases

被引：19

作者：

Shridas, Preetha ^{[1
,2
,3
]}

Patrick, Avery C. ^{[4
]}

Tannock, Lisa R. ^{[1
,2
,3
,5
]}

机构：

[1] Univ Kentucky, Dept Internal Med, Lexington, KY 40536 USA

[2] Univ Kentucky, Saha Cardiovasc Res Ctr, Lexington, KY 40536 USA

[3] Univ Kentucky, Barnstable Brown Diabet Ctr, Lexington, KY 40536 USA

[4] Univ Kentucky, Pharmacol & Nutr Sci, Lexington, KY 40536 USA

[5] Univ Kentucky, Vet Affairs Lexington, Lexington, KY 40536 USA

来源：

BIOMOLECULES | 2021年 / 11卷 / 12期

基金：

美国国家卫生研究院;

关键词：

cardiovascular disease; abdominal aortic aneurysm; serum amyloid A; HDL; HIGH-DENSITY-LIPOPROTEIN; C-REACTIVE PROTEIN; B-CONTAINING LIPOPROTEINS; NECROSIS-FACTOR-ALPHA; NF-KAPPA-B; ATHEROSCLEROTIC LESIONS; NLRP3; INFLAMMASOME; CHOLESTEROL EFFLUX; A PROTEIN; MACROPHAGE CHOLESTEROL;

D O I：

10.3390/biom11121883

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Epidemiological data positively correlate plasma serum amyloid A (SAA) levels with cardiovascular disease severity and mortality. Studies by several investigators have indicated a causal role for SAA in the development of atherosclerosis in animal models. Suppression of SAA attenuates the development of angiotensin II (AngII)-induced abdominal aortic aneurysm (AAA) formation in mice. Thus, SAA is not just a marker for cardiovascular disease (CVD) development, but it is a key player. However, to consider SAA as a therapeutic target for these diseases, the pathway leading to its involvement needs to be understood. This review provides a brief description of the pathobiological significance of this enigmatic molecule. The purpose of this review is to summarize the data relevant to its role in the development of CVD, the pitfalls in SAA research, and unanswered questions in the field.

引用

页数：13

共 123 条

[1] Serum Amyloid A Activates the NLRP3 Inflammasome and Promotes Th17 Allergic Asthma in Mice [J].