The role of microRNAs in skeletal muscle health and disease

被引：58
作者：
Kirby, Tyler J. [1 ,2 ]
Chaillou, Thomas [1 ,2 ]
McCarthy, John J. [1 ,2 ]
机构：
[1] Univ Kentucky, Ctr Muscle Biol, Lexington, KY 40536 USA
[2] Univ Kentucky, Dept Physiol, Coll Med, Lexington, KY 40536 USA
来源：
FRONTIERS IN BIOSCIENCE-LANDMARK | 2015年 / 20卷
关键词：
MyomiR; Exercise; Hypertrophy; Atrophy; Muscular dystrophy; Review; PROMOTES MYOGENIC DIFFERENTIATION; PROGENITOR-CELL PROLIFERATION; DUCHENNE MUSCULAR-DYSTROPHY; ACUTE ENDURANCE EXERCISE; DOWN-REGULATION; MYOBLAST DIFFERENTIATION; TRANSCRIPTION FACTOR; RESISTANCE EXERCISE; INSULIN-RESISTANCE; SATELLITE CELLS;
D O I：
10.2741/4298
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Over the last decade non-coding RNAs have emerged as importance regulators of gene expression. In particular, microRNAs are a class of small RNAs of similar to 22 nucleotides that repress gene expression through a post-transcriptional mechanism. MicroRNAs have been shown to be involved in a broader range of biological processes, both physiological and pathological, including myogenesis, adaptation to exercise and various myopathies. The purpose of this review is to provide a comprehensive summary of what is currently known about the role of microRNAs in skeletal muscle health and disease.
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收藏
页码：37 / 77
页数：41
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