Systemic small molecule TREX1 inhibitors to selectively activate STING in the TME of metastatic disease

被引：0

作者：

Francica, Brian ^{[1
]}

Burdette, Dara ^{[1
]}

Clark, Ryan ^{[1
]}

Cope, Jamie ^{[1
]}

Freund, David ^{[1
]}

Holtz, Anja ^{[1
]}

Prasit, Peppi ^{[1
]}

Whiting, Chan ^{[1
]}

Dubensky, Thomas W. ^{[1
]}

机构：

[1] Tempest Therapeut, South San Francisco, CA USA

来源：

CANCER RESEARCH | 2022年 / 82卷 / 12期

关键词：

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

2075

引用

页数：2

共 23 条

[1] Small Molecule TREX1 Inhibitors as Novel Immunotherapies
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[2] Development of small molecule inhibitors/agonists targeting STING for disease
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[3] Novel de novo TREX1 mutation in a patient with retinal vasculopathy with cerebral leukoencephalopathy and systemic manifestations mimicking demyelinating disease
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[5] Novel heterozygous TREX1 mutation in a juvenile systemic lupus erythematosus patient with severe cutaneous involvement treated successfully with Jak-inhibitors: a case report
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[6] DWL-4-140: A allene small molecule targeting STING that alleviates lupus-like phenotype in Trex1- /- mice
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[7] THE FIRST-IN-CLASS SMALL MOLECULE TREX1 INHIBITOR CPI-381 DEMONSTRATES TYPE I IFN INDUCTION AND SENSITIZATION OF TUMORS TO IMMUNE CHECKPOINT BLOCKADE
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[8] ENPP1, an Old Enzyme with New Functions, and Small Molecule Inhibitors-A STING in the Tale of ENPP1
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[9] Pharmacology of small molecule inhibitors of GYS1 in a mouse model of Pompe disease
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[10] Small-molecule inhibitors against type 1 pili selectively target uropathogenic E. coli in the gut and bladder
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