Perspectives on Lymphangiogenesis and Angiogenesis in Cancer

被引：31

作者：

Holopainen, Tanja

Bry, Maija ^{[1
]}

Alitalo, Kari ^{[1
]}

Saaristo, Anne ^{[1
,2
]}

机构：

[1] Univ Helsinki, Dept Pathol, Lab Mol Canc Biol,Cent Hosp,Biomedium Helsinki, Res Program Unit,Dept Pathol,Haartman Inst,Inst M, Helsinki 00014, Finland

[2] Turku Univ, Cent Hosp, Turun, Finland

来源：

JOURNAL OF SURGICAL ONCOLOGY | 2011年 / 103卷 / 06期

基金：

芬兰科学院;

关键词：

vascular endothelial growth factors; vascular biology; lymphedema; ENDOTHELIAL GROWTH-FACTOR; INHIBITS TUMOR-GROWTH; LYMPH-NODE; FACTOR-C; FACTOR-B; FACTOR RECEPTOR-2; VEGF-C; CELLS; METASTASIS; PROMOTES;

D O I：

10.1002/jso.21808

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Tumor-associated neovascularization allows tumor cells to express their critical growth advantage, whereas lymphatic invasion is crucial for the metastatic process. Various growth factors stimulate blood and lymphatic neovascularization and modulate vessel permeability in tumors. The first anti-angiogenic drugs are already in routine use, and new anti-vascular therapeutics are evaluated in clinical trials. Conversely, pro-lymphangiogenic therapy could be implemented to treat cancer survivors suffering from secondary lymphedema. J. Surg. Oncol. 2011;103:484-488. (C) 2011 Wiley-Liss, Inc.

引用

页码：484 / 488

页数：5

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