Synthesis and antibacterial activity of 4-aryl-2-hydroxy-4-oxo-2-butenoic (aroylpyruvic) acids N-(4-guanidylsulfonylphenyl)amides

被引：7

作者：

Gein, V. L. ^{[1
]}

Bobrovskaya, O. V. ^{[1
]}

Kovtonogova, I. V. ^{[1
]}

Novikova, V. V. ^{[1
]}

机构：

[1] Perm State Pharmaceut Acad, Perm 614990, Russia

来源：

RUSSIAN JOURNAL OF GENERAL CHEMISTRY | 2015年 / 85卷 / 04期

关键词：

aroylpyruvic acids N-(4-guanidylsulfonylphenyl) amides; 4-aminobenzenesulfonylguanidine; sulgin; antibacterial activity; NUCLEOPHILIC-REAGENTS; OXALYL DERIVATIVES; AROMATIC-AMINES; MECHANISMS; CHEMISTRY; CATALYSIS;

D O I：

10.1134/S1070363215040106

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Reaction of methyl aroylpyruvates with 4-aminobenzolsulfonylguanidine in acetic acid in the presence of anhydrous sodium acetate afforded N-(4-guanidylsulfonylphenyl)amides of 4-aryl-2-hydroxy-4-oxo-2-butenoic acids. Antibacterial activity of the synthesized compounds was studied.

引用

页码：833 / 836

页数：4

共 13 条

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Gein, V. L.
Bobrovskaya, O. V.
Sitnikova, A. A.
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