Novel carriers ensuring enhanced anti-cancer activity of Cornus mas (cornelian cherry) bioactive compounds

被引：34

作者：

Radbeh, Zarrin ^{[1
]}

Asefi, Narmela ^{[1
]}

Hamishehkar, Hamed ^{[2
]}

Roufegarinejad, Leila ^{[1
]}

Pezeshki, Akram ^{[3
]}

机构：

[1] Islamic Azad Univ, Tabriz Branch, Dept Food Sci & Technol, Tabriz, Iran

[2] Tabriz Univ Med Sci, Drug Appl Res Ctr, Tabriz, Iran

[3] Univ Tabriz, Dept Food Sci & Technol, Fac Agr, Tabriz, Iran

来源：

BIOMEDICINE & PHARMACOTHERAPY | 2020年 / 125卷

关键词：

Cornus mas; Antioxidant activity; Nano-cubosomes; Bioactive compounds; Colorectal cancer; Eudragit (R) S100; NANOPARTICLES; DELIVERY; ANTHOCYANINS; POLYPHENOLS; CUBOSOME; ENCAPSULATION; PARTICLES; STABILITY; LIPOSOMES; APOPTOSIS;

D O I：

10.1016/j.biopha.2020.109906

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Cornusmas' bioactive compounds are powerful antioxidants. In this study, we evaluated the antioxidant activity of the encapsulated bioactive compounds of Cornus mas extract (CME) and its release in semi digestive condition via enteric coated nanocarriers (NCs). The two forms of CME, encapsulated into enteric coated nanocarriers (CME-NCs) and free CME, were studied to determine the effect of encapsulation on the stability of antioxidants. Then, their effect on cell cycle, cell viability and apoptosis of cancer cells were studied. The characterization analysis reported the mean particle size and zeta potential value of NCs equal to 22.7 +/- 6.58 nm and -16 +/- 5 mV. The results showed that CME-NCs could improve IC50 value 1.33 and 1.47 times more than the free CME after 24 and 48 h of incubation. These findings confirmed that CME-NCs could stop the cells proliferation in G1 phase, and caused apoptosis in cancer cell line HT-29.

引用

页数：8

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