Human β-secretase (BACE) and BACE inhibitors

被引：140
作者：
John, V
Beck, JP
Bienkowski, MJ
Sinha, S
Heinrikson, RL
机构：
[1] Elan Pharmaceut, San Francisco, CA 94080 USA
[2] Pfizer Corp, Kalamazoo, MI 49007 USA
来源：
JOURNAL OF MEDICINAL CHEMISTRY | 2003年 / 46卷 / 22期
关键词：
D O I：
10.1021/jm030247h
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
引用
收藏
页码：4625 / 4630
页数：6
相关论文
共 43 条
[1]   The gene encoding DRAP (BACE2), a glycosylated transmembrane protein of the aspartic protease family, maps to the Down critical region [J].
Acquati, F ;
Accarino, M ;
Nucci, C ;
Fumagalli, P ;
Jovine, L ;
Ottolenghi, S ;
Taramelli, R .
FEBS LETTERS, 2000, 468 (01) :59-64
[2]  
Beck J. P., 2002, [No title captured], Patent No. [WO 02/002520, 02002520]
[3]   A furin-like convertase mediates propeptide cleavage of BACE, the Alzheimer's β-secretase [J].
Bennett, BD ;
Denis, P ;
Haniu, M ;
Teplow, DB ;
Kahn, S ;
Louis, JC ;
Citron, M ;
Vassar, R .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (48) :37712-37717
[4]  
BHISETTI GR, 2002, Patent No. 0288101
[5]   BACE1 is the major β-secretase for generation of Aβ peptides by neurons [J].
Cai, HB ;
Wang, YS ;
McCarthy, D ;
Wen, HJ ;
Borchelt, DR ;
Price, DL ;
Wong, PC .
NATURE NEUROSCIENCE, 2001, 4 (03) :233-234
[6]   Biomedicine - A portrait of Alzheimer secretases - New features and familiar faces [J].
Esler, WP ;
Wolfe, MS .
SCIENCE, 2001, 293 (5534) :1449-1454
[7]  
Etcheberrigaray R., 2002, Patent, Patent No. [WO. 02/96897, 0296897]
[8]  
Fang L. Y., 2002, [No title captured], Patent No. [02002505, WO 02/002505]
[9]  
Fang L. Y., 2002, [No title captured], Patent No. [WO 02/002506, 02002506]
[10]  
Fisher J. F., 2003, [No title captured], Patent No. [WO 03/029169, 03029169]
12345