The intramolecular carboxyarylation approach to podophyllotoxin

被引：73

作者：

Reynolds, AJ

Scott, AJ

Turner, CI

Sherburn, MS ^{[1
]}

机构：

[1] Australian Natl Univ, Res Sch Chem, Canberra, ACT 0200, Australia

[2] Univ Sydney, Sch Chem, Sydney, NSW 2006, Australia

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2003年 / 125卷 / 40期

关键词：

D O I：

10.1021/ja0376588

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Since 1960, only seven plant-derived anticancer drugs have received FDA approval for commercial production. Two are semisynthetic derivatives of podophyllotoxin. This paper describes concise, highly convergent, and conceptually novel approaches to (-)-podophyllotoxin and its enantiomer. These highly convergent syntheses feature a late-stage domino radical reaction to install the lactone ring and the pendant trimethoxyphenyl group. Copyright © 2003 American Chemical Society.

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收藏

页码：12108 / 12109

页数：2

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