Comprehensive analysis of normal adjacent to tumor transcriptomes

被引：396

作者：

Aran, Dvir ^{[1
]}

Camarda, Roman ^{[2
,3
]}

Odegaard, Justin ^{[4
]}

Paik, Hyojung ^{[1
,8
]}

Oskotsky, Boris ^{[1
]}

Krings, Gregor ^{[5
]}

Goga, Andrei ^{[2
,6
,7
]}

Sirota, Marina ^{[1
]}

Butte, Atul J. ^{[1
]}

机构：

[1] Univ Calif San Francisco, Inst Computat Hlth Sci, San Francisco, CA 94158 USA

[2] Univ Calif San Francisco, Dept Cell & Tissue Biol, San Francisco, CA 94143 USA

[3] Univ Calif San Francisco, Biomed Sci Grad Program, San Francisco, CA 94143 USA

[4] Stanford Univ, Med Ctr, Dept Pathol, Stanford, CA 94305 USA

[5] Univ Calif San Francisco, Dept Pathol, San Francisco, CA 94143 USA

[6] Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA

[7] Univ Calif San Francisco, Helen Diller Family Comprehens Canc Ctr, San Francisco, CA 94115 USA

[8] Korea Inst Sci & Technol Informat, Biomed HPC Res Ctr, 245 Daehak Ro, Daejeon, South Korea

来源：

NATURE COMMUNICATIONS | 2017年 / 8卷

基金：

美国国家卫生研究院;

关键词：

INTEGRATED GENOMIC CHARACTERIZATION; DEMONSTRATE FIELD CANCERIZATION; HUMAN HOUSEKEEPING GENES; BREAST-CANCER PATIENTS; NORMAL TISSUE ADJACENT; PROSTATE-CANCER; ENDOTHELIAL-CELLS; EXPRESSION; CARCINOMA; MACROPHAGES;

D O I：

10.1038/s41467-017-01027-z

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Histologically normal tissue adjacent to the tumor (NAT) is commonly used as a control in cancer studies. However, little is known about the transcriptomic profile of NAT, how it is influenced by the tumor, and how the profile compares with non-tumor-bearing tissues. Here, we integrate data from the Genotype-Tissue Expression project and The Cancer Genome Atlas to comprehensively analyze the transcriptomes of healthy, NAT, and tumor tissues in 6506 samples across eight tissues and corresponding tumor types. Our analysis shows that NAT presents a unique intermediate state between healthy and tumor. Differential gene expression and protein-protein interaction analyses reveal altered pathways shared among NATs across tissue types. We characterize a set of 18 genes that are specifically activated in NATs. By applying pathway and tissue composition analyses, we suggest a pan-cancer mechanism of pro-inflammatory signals from the tumor stimulates an inflammatory response in the adjacent endothelium.

引用

页数：14

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